Results 71 to 80 of about 571,324 (373)

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids

open access: yesMicromachines, 2021
Optical DNA mapping (ODM) has developed into an important technique for DNA analysis, where single DNA molecules are sequence-specifically labeled and stretched, for example, in nanofluidic channels.
Sriram KK   +6 more
doaj   +1 more source

Multiplex Immunoassay and Bead Based Multiplex [PDF]

open access: yes, 2012
Protein immunoassays provide information about quantities and forms of endogenous proteins. Uniplex enzyme immunoassays like Elisa have been the workhorse for protein measurement for decades, but they can be laborious and expensive and consume relatively large amounts of specimen.
openaire   +3 more sources

Spatial multiplexing of soliton microcombs [PDF]

open access: yesNature Photonics, 2018
Dual-comb interferometry utilizes two optical frequency combs to map the optical field’s spectrum to a radio-frequency signal without using moving parts, allowing improved speed and accuracy.
E. Lucas   +7 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Compendium of Plant-Specific CRISPR Vectors and Their Technical Advantages

open access: yesLife, 2021
CRISPR/Cas mediated genome editing is a revolutionary approach for manipulating the plant genome. However, the success of this technology is highly dependent on selection of a specific vector and the other components.
Anshu Alok   +5 more
doaj   +1 more source

Diversity versus Multiplexing at Finite Blocklength

open access: yes, 2014
A finite blocklenth analysis of the diversity-multiplexing tradeoff is presented, based on nonasymptotic bounds on the maximum channel coding rate of multiple-antenna block-memoryless Rayleigh-fading channels.The bounds in this paper allow one to ...
Durisi, Giuseppe   +3 more
core   +1 more source

Graphlets in Multiplex Networks [PDF]

open access: yesScientific Reports, 2020
AbstractWe develop graphlet analysis for multiplex networks and discuss how this analysis can be extended to multilayer and multilevel networks as well as to graphs with node and/or link categorical attributes. The analysis has been adapted for two typical examples of multiplexes: economic trade data represented as a 957-plex network and 75 social ...
Kristijan Petrovski   +3 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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