Results 41 to 50 of about 302,425 (284)

Ordering the Multiple Pathways of Apoptosis

Trends in Cardiovascular Medicine, 1997
Apoptosis plays an important role in development, homeostasis, and disease. Current work has suggested that apoptosis can be evoked by multiple stimuli that, in turn, initiate distinct death pathways. Recently, exciting advances have been made in the understanding of biochemical pathways that regulate apoptotic processes.
D S, Park, L, Stefanis, L A, Greene
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Additive and multiplicative hazards modeling for recurrent event data analysis

BMC Medical Research Methodology, 2011
Background Sequentially ordered multivariate failure time or recurrent event duration data are commonly observed in biomedical longitudinal studies. In general, standard hazard regression methods cannot be applied because of correlation between recurrent
Zhang Xu, Lim Hyun J
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Mesoscopic description of the annealed Ising model and Multiplicative noise

, 1998
A new type of Langevin equation exhibiting a non trivial phase transition associated with the presence of multiplicative noise is introduced. The equation is derived as a mesoscopic representation of the microscopic annealed Ising model (AIM) proposed by
A. Becker, A. S. Pikovsky, C. R. Doering, C. Van den Broeck, C. Van den Broeck, C. W. Gardiner, D. Amit, G. Grinstein, J. García-Ojalvo, J. García-Ojalvo, J. M. Parrondo, K. Weisenfeld, L. Onsager, M. F. Thorpe, Miguel A. Muñoz, P. C. Hohenberg, P. L. Garrido, P. Pechukas, R. Benzi, R. Müller, S. Kim, W. Genovese, W. Horsthemke, Walter Genovese, Y. Tu   +24 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A product autoregressive model with log-Laplace marginal distribution

Statistica, 2013
The log-Laplace distribution and its properties are considered. Some important properties like multiplicative infinite divisibility, geometric multiplicative infinite divisibility and self-decomposability are discussed.
Kanichukattu K. Jose, Manu Mariam Thomas
doaj   +1 more source

A Tutte polynomial inequality for lattice path matroids

, 2016
Let $M$ be a matroid without loops or coloops and let $T(M;x,y)$ be its Tutte polynomial. In 1999 Merino and Welsh conjectured that $$\max(T(M;2,0), T(M;0,2))\geq T(M;1,1)$$ holds for graphic matroids.
Alfonsín, Jorge Luis Ramírez, Knauer, Kolja, Martínez-Sandoval, Leonardo   +2 more
core   +4 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source