Results 211 to 220 of about 504,368 (352)

A Cautionary Note on Regional Consistency Evaluation With Multiple Primary Endpoints in Multiregional Clinical Trials. [PDF]

Pharm Stat
Homma G.
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Causal Inference, Statistical Assumptions, and Natural-Language-Processing Artefacts in Evaluating Medical Students' Use of Generative Artificial Intelligence [Letter]. [PDF]

Adv Med Educ Pract
Feng Z.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

A Framework for the Complexity of High-Multiplicity Scheduling Problems. [PDF]

Klundert, J. van de, Grigoriev, A., Crama, Y., Brauner, N   +3 more
core   +2 more sources

Mixed malaria infections: A critical review and Detect-Characterise-Act surveillance framework. [PDF]

Curr Res Parasitol Vector Borne Dis
Igwe MC, Alum EU.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DRL-Based LEO Constellation Design for Regional Navigation Enhancement. [PDF]

Sensors (Basel)
Rui Z, Zeng F, Ouyang X, Chen L.
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples. [PDF]

Nat Genet
Calonaci N, Krasniqi E, Colic D, Scalera S, Gandolfi G, Milite S, Bräutigam K, Sottoriva A, Graham TA, Egidi L, Ricciuti B, Maugeri-Saccà M, Caravagna G.   +12 more
europepmc   +1 more source