The many faces of the GID/CTLH E3 ligase complex. [PDF]
Alpi AF +3 more
europepmc +1 more source
Subcellular targeting of survivin peptides: A multi-axis approach to cancer therapy. [PDF]
Pathania AS.
europepmc +1 more source
C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling. [PDF]
Qiao Y +20 more
europepmc +1 more source
Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation. [PDF]
Alshehri A +6 more
europepmc +1 more source
[Rearrangement of chromatin structure by multiprotein complexes].
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ACEMBLing a Multiprotein Transmembrane Complex
Nature Methods, 2015Structural and functional studies of many multiprotein complexes depend on recombinant-protein overexpression. Rapid revision of expression experiments and diversification of the complexes are often crucial for success of these projects; therefore, automation is increasingly indispensable.
Joanna Komar +4 more
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Multiprotein complexes governing Wnt signal transduction
Current Opinion in Cell Biology, 2018Three multiprotein complexes have key roles in transducing Wnt signals from the plasma membrane to the cell nucleus - the β-catenin destruction complex, or Axin degradasome, which targets the Wnt effector β-catenin for proteasomal degradation in the absence of Wnt; the Wnt signalosome, assembled by polymerization of Dishevelled upon Wnt engaging its ...
Melissa, Gammons, Mariann, Bienz
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Multiprotein complex signaling and the plasticity problem
Current Opinion in Neurobiology, 2001Synaptic transmission of distinct patterns of spikes, or 'neural code', leads to plastic changes in synapses and other parts of the neuron, as well as learning in animals. Recent findings indicate that specialized multiprotein structures associated with neurotransmitter receptors and cell-adhesion proteins function as molecular devices that both read ...
S G, Grant, T J, O'Dell
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Baculovirus expression system for heterologous multiprotein complexes
Nature Biotechnology, 2004The discovery of large multiprotein complexes in cells has increased the demand for improved heterologous protein production techniques to study their molecular structure and function. Here we describe MultiBac, a simple and versatile system for generating recombinant baculovirus DNA to express protein complexes comprising many subunits.
Imre, Berger +2 more
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MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION
Annual Review of Biophysics and Biomolecular Structure, 1999▪ Abstract Transcription in eukaryotes is frequently regulated by a mechanism termed combinatorial control, whereby several different proteins must bind DNA in concert to achieve appropriate regulation of the downstream gene. X-ray crystallographic studies of multiprotein complexes bound to DNA have been carried out to investigate the molecular ...
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