Protease and DNase Activities of a Very Stable High-Molecular-Mass Multiprotein Complex from Sea Cucumber Eupentacta fraudatrix [PDF]
, 2022 Anna M. Timofeeva +4 more
openalex +1 more source
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes
Protein Science, Volume 35, Issue 5, May 2026.Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni +9 more
wiley +1 more source
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4<sup>+</sup> T Cells. [PDF]
Front Immunol, 2021 Luff DH +8 more
europepmc +1 more source
Proteolytic control of mitochondrial protein translocases
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley +1 more source
Alphafuser: a parsimonious approach to predicting higher‐order protein complexes
Acta Crystallographica Section D, Volume 82, Issue 5, Page 421-433, May 2026.Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin +5 more
wiley +1 more source
Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes
Annals of Applied Biology, Volume 188, Issue 3, Page 947-961, May 2026.This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy +3 more
wiley +1 more source
Stepwise order in protein complex assembly: approaches and emerging themes
Open BiologyProtein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how they work, but we still know relatively little about how
Michael T. Brown, Michael A. McMurray
doaj +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT The NLRP3 inflammasome is a central mediator of innate immunity and a key driver of inflammatory and neurodegenerative diseases. VENT‐02 is orally bioavailable, central nervous system‐penetrant, selective small‐molecule inhibitor of NLRP3. This first‐in‐human, randomized, double‐blind, placebo‐controlled study assessed the safety, tolerability,
Lisanne C. A. Smidt +14 more
wiley +1 more source
The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions [PDF]
, 1997 Michael Hagmann +2 more
openalex +1 more source
Genes to Cells, Volume 31, Issue 3, May 2026.Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino +2 more
wiley +1 more source