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Multiscale Cancer Modeling [PDF]

Annual Review of Biomedical Engineering, 2011
Simulating cancer behavior across multiple biological scales in space and time, i.e., multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine hypotheses, focus experiments, and enable more accurate predictions. A growing number of examples illustrate the value of this approach in providing quantitative insights in the
Deisboeck, Thomas S., Wang, Zhihui, Macklin, Paul, Cristini, Vittorio   +3 more
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Novel multiscale modeling tool applied to Pseudomonas aeruginosa biofilm formation. [PDF]

PLoS ONE, 2013
Multiscale modeling is used to represent biological systems with increasing frequency and success. Multiscale models are often hybrids of different modeling frameworks and programming languages. We present the MATLAB-NetLogo extension (MatNet) as a novel
Matthew B Biggs, Jason A Papin
doaj   +2 more sources

Investigating the effects of intersection flow localization in equivalent-continuum-based upscaling of flow in discrete fracture networks [PDF]

Solid Earth, 2021
Predicting effective permeabilities of fractured rock masses is a crucial component of reservoir modeling. Its often realized with the discrete fracture network (DFN) method, whereby single-phase incompressible fluid flow is modeled in discrete ...
M. O. Kottwitz, M. O. Kottwitz, A. A. Popov, A. A. Popov, S. Abe, B. J. P. Kaus, B. J. P. Kaus   +6 more
doaj   +1 more source

Data‐Driven Stochastic Lie Transport Modeling of the 2D Euler Equations

Journal of Advances in Modeling Earth Systems, 2023
In this paper, we propose and assess several stochastic parametrizations for data‐driven modeling of the two‐dimensional Euler equations using coarse‐grid SPDEs.
Sagy R. Ephrati, Paolo Cifani, Erwin Luesink, Bernard J. Geurts   +3 more
doaj   +1 more source

Multiscale brain modelling [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
A central difficulty of brain modelling is to span the range of spatio-temporal scales from synapses to the whole brain. This paper overviews results from a recent model of the generation of brain electrical activity that incorporates both basic microscopic neurophysiology and large-scale brain anatomy to predict brain electrical activity at scales ...
P A, Robinson, C J, Rennie, D L, Rowe, S C, O'Connor, E, Gordon   +4 more
openaire   +2 more sources

High energy barriers for edge dislocation motion in body-centered cubic high entropy alloys

npj Computational Materials, 2021
Recent theory proposes that edge dislocations in random body-centered cubic (BCC) high entropy alloys have high barriers for motion, conveying high strengths up to high temperatures.
R. E. Kubilay, A. Ghafarollahi, F. Maresca, W. A. Curtin   +3 more
doaj   +1 more source

Partial Learning Using Partially Explicit Discretization for Multicontinuum/Multiscale Problems with Limited Observation: Dual Continuum Heterogeneous Poroelastic Media Simulation

Mathematics, 2022
In this paper, we consider the poroelasticity problem in heterogeneous media. The mathematical model is described by a coupled system of equations for displacement and pressure in the coupled dual continuum porous media.
Aleksei Tyrylgin, Sergei Stepanov, Dmitry Ammosov, Aleksandr Grigorev, Maria Vasilyeva   +4 more
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Multiscale Modeling in Biology [PDF]

American Scientist, 2007
The 1966 science-fction film Fantastic Voyage captured the public imagination with a clever idea: what fantastic things might we see and do if we could minaturize ourselves and travel through the bloodstream as corpuscles do? (This being Hollywood, the answer was that we'd save a fellow scientist from evildoers.)
Schnell, S, Grima, R, Maini, P
openaire   +3 more sources

Origins of the change in mechanical strength of silicon/gold nanocomposites during irradiation

Scientific Reports, 2021
Silicon-based layered nanocomposites, comprised of covalent-metal interfaces, have demonstrated elevated resistance to radiation. The amorphization of the crystalline silicon sublayer during irradiation and/or heating can provide an additional mechanism ...
Elton Y. Chen, Cameron P. Hopper, Raghuram R. Santhapuram, Rémi Dingreville, Arun K. Nair   +4 more
doaj   +1 more source

Multiscale models of angiogenesis [PDF]

IEEE Engineering in Medicine and Biology Magazine, 2009
Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound ...
Amina A, Qutub, Feilim, Mac Gabhann, Emmanouil D, Karagiannis, Prakash, Vempati, Aleksander S, Popel   +4 more
openaire   +2 more sources