Results 91 to 100 of about 19,858 (239)

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, EarlyView.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

Biorevitalizant with multitargeted action

Russian Journal of Skin and Venereal Diseases, 2016
Biorevitalization is an intradermal injection of unstabilized hyaluronic acid to improve skin texture. The article presents the results of the drug Revi for the treatment of rosacea and biological aging by stimulating its internal physiological reserves and it can be recommended in conditions such as rosacea, the biological aging of the skin.
E. V Lipova, Y. G Suhovei, N. V Griazeva
openaire   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Spirofused Tetrahydroisoquinoline-Oxindole Hybrids (Spiroquindolones) as Potential Multitarget Antimalarial Agents: Preliminary Hit Optimization and Efficacy Evaluation in Mice

, 2022
Noella Molisa Efange, Maloba M. M. Lobe, Lauve Rachel Tchokouaha Yamthé, Jeannette Nina Magoudjou Pekam, Protus Arrey Tarkang, Lawrence Ayong, Simon M. N. Efange   +6 more
openalex   +2 more sources

Salvia miltiorrhiza‐Derived Vesicle‐Like Nanoparticles Functionalised Hydrogel With Excellent Ability of Oxidative Stress Modulation and Anti‐Cardiomyocyte Apoptosis for Sepsis‐Induced Myocardial Injury

Plant Biotechnology Journal, EarlyView.
ABSTRACT In the process of myocardial cell structural and functional damage caused by various factors, current therapeutic strategies primarily focus on restoring myocardial blood supply, often neglecting the inherent complex microenvironment triggered by elevated reactive oxygen species (ROS) levels during myocardial injury.
Zhichao Liu, Shixiang Chen, Baomin Dou, Zhen Shen, Hao Liu, Xizhen Wang, Liyue Zhu, Yue Qiu, Zhongxi Lyu, Te Ba, Kuicheng Li, Jinhong Chen, Ningcen Li   +12 more
wiley   +1 more source

Drug discovery and computational strategies in the multitarget drugs era

Brazilian Journal of Pharmaceutical Sciences, 2018
The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases.
Jéssika de Oliveira Viana, Mayara Barbalho Félix, Mayara dos Santos Maia, Vanessa de Lima Serafim, Luciana Scotti, Marcus Tullius Scotti   +5 more
doaj   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

Autonomous Drone Swarm Navigation and Multitarget Tracking With Island Policy-Based Optimization Framework [PDF]

, 2022
Suleman Qamar, Saddam Hussain Khan, Muhammad Arif Arshad, Maryam Qamar, Jeonghwan Gwak, Asifullah Khan   +5 more
openalex   +1 more source

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation [PDF]

, 2022
R.S. Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Hélène Martin, José Marco‐Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jóźwiak, Lhassane Ismaïli   +12 more
openalex   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source