Results 91 to 100 of about 34,376 (260)
Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou +6 more
wiley +1 more source
Frontiers in Chemistry, 2018 In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs ...
Bart I. Roman +5 more
doaj +1 more source
Multi-Object Tracking with Interacting Vehicles and Road Map Information
, 2018 In many applications, tracking of multiple objects is crucial for a perception of the current environment. Most of the present multi-object tracking algorithms assume that objects move independently regarding other dynamic objects as well as the static ...
Danzer, Andreas +2 more
core +1 more source
iNew Medicine, EarlyView.Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley +1 more source
Poisson multi-Bernoulli conjugate prior for multiple extended object filtering
, 2019 This paper presents a Poisson multi-Bernoulli mixture (PMBM) conjugate prior for multiple extended object filtering. A Poisson point process is used to describe the existence of yet undetected targets, while a multi-Bernoulli mixture describes the ...
Fatemi, Maryam +2 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen +7 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2017 Wound healing involves an orchestrated response that engages multiple processes, such as hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation.
Georges St. Laurent +15 more
doaj +1 more source
Duloxetine, a Multitarget Drug [PDF]
Advances in Pharmacoepidemiology & Drug Safety, 2012 This review presents an overview of the multi targets of the duloxetine drug which was a product of the famous Eli Lilly Company. Although there is little evidence that the studies reproduce, it is clear that different transmitters or receptor types are involved in hyperalgesia and chronic pain which duloxetine mainly targets.
openaire +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao +7 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source