Results 211 to 220 of about 19,858 (239)
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Multitarget Antithrombotic Drugs
Current Topics in Medicinal Chemistry, 2011Thromboembolic disorders are still the leading causes of morbidity and mortality in developed societies. Therefore, prophylaxis and treatment of arterial and venous thrombosis are among the main therapeutic challenges nowadays. Simultaneous action on several targets involved in pathology of thrombosis offers potential advantages compared to existing ...
Miloš, Ilić +2 more
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Multitarget Sparse Latent Regression
IEEE Transactions on Neural Networks and Learning Systems, 2018Multitarget regression has recently generated intensive popularity due to its ability to simultaneously solve multiple regression tasks with improved performance, while great challenges stem from jointly exploring inter-target correlations and input-output relationships.
Xiantong Zhen +6 more
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JAMA
To the Editor The study by Dr Barnell and colleagues1 raises methodological and clinical concerns. First, sessile serrated lesions (SSLs) 1 cm or larger are widely considered to be advanced precancerous lesions comparable to advanced adenomas, and their categorization as a nonfinding and part of the specificity calculation is unconventional.
Ransohoff, David F. +2 more
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To the Editor The study by Dr Barnell and colleagues1 raises methodological and clinical concerns. First, sessile serrated lesions (SSLs) 1 cm or larger are widely considered to be advanced precancerous lesions comparable to advanced adenomas, and their categorization as a nonfinding and part of the specificity calculation is unconventional.
Ransohoff, David F. +2 more
openaire +4 more sources
Multitarget range-azimuth tracker
IEEE Transactions on Aerospace and Electronic Systems, 2015We focus on the design of a Kalman filter-based algorithm to track multiple targets in range and azimuth. The detection stage implements a multitarget strategy aimed at collecting and eventually processing all target measurements. Existing tracks are updated using a joint probabilistic data association (JPDA) algorithm to handle the data association ...
BANDIERA, Francesco +2 more
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Pemetrexed: A multitargeted antifolate
Clinical Therapeutics, 2005The US Food and Drug Administration approved pemetrexed in February 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin in patients with unresectable disease or for whom curative surgery is not an option. Pemetrexed is the first agent approved for the treatment of MPM.
Kristan D, Rollins, Celeste, Lindley
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Computational Multitarget Drug Design
Journal of Chemical Information and Modeling, 2017Designing drugs that can simultaneously interact with multiple targets is a promising approach for treating complicated diseases. Compared to using combinations of single target drugs, multitarget drugs have advantages of higher efficacy, improved safety profile, and simpler administration.
Weilin Zhang, Jianfeng Pei, Luhua Lai
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Multitargeted Treatment of Cancer Cachexia
Critical Reviews™ in Oncogenesis, 2012Cancer cachexia is defined as a multifactorial syndrome characterized by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. The prominent clinical feature of cachexia is weight loss in adults. Anorexia, inflammation,
MADEDDU, CLELIA +2 more
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Multitarget bayes filtering via first-order multitarget moments
IEEE Transactions on Aerospace and Electronic Systems, 2003The theoretically optimal approach to multisensor-multitarget detection, tracking, and identification is a suitable generalization of the recursive Bayes nonlinear filter. Even in single-target problems, this optimal filter is so computationally challenging that it must usually be approximated. Consequently, multitarget Bayes filtering will never be of
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Fast JPDA multitarget tracking algorithm
Applied Optics, 1989Multitarget tracking requires assigning probabilities that measurements are associated with particular targets. A new and efficient algorithm to achieve this is detailed. Its implementation on an analog optical processor using a new and cost-effective frequency-multiplexing technique is discussed.
J L, Fisher, D P, Casasent
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Rationally Designed Multitarget Anticancer Agents
Current Medicinal Chemistry, 2013Balanced modulation of multiple targets is an attractive therapeutic strategy in treating complex diseases including cancer. Comparing with drugs combination, single molecule modulating desirable multiple targets has advantages in pharmacokinetic and pharmacodynamics.
Zhuo, Chen +4 more
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