Results 101 to 110 of about 93,551 (286)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Multivariate error function based neural network approximations

Journal of Numerical Analysis and Approximation Theory, 2014
Here we present multivariate quantitative approximations of real and complex valued continuous multivariate functions on a box or \(\mathbb{R}^{N},\) \(N\in \mathbb{N}\), by the multivariate quasi-interpolation, Baskakov type and quadrature type neural ...
George A. Anastassiou
doaj   +2 more sources

Harmonic functions on multiplicative graphs and interpolation polynomials [PDF]

, 1999
We construct examples of nonnegative harmonic functions on certain graded graphs: the Young lattice and its generalizations. Such functions first emerged in harmonic analysis on the infinite symmetric group.
Borodin, Alexei, Olshanski, Grigori
core   +2 more sources

An estimate for multivariate interpolation

Journal of Approximation Theory, 1985
An estimate of the \(L^ p=L^ p(R^ n)\) norm of a function is given in terms of its values on a (not necessarily regular) grid of points and the \(L^ p\) norms of its k-th order derivatives, \(kp>n\). The result is useful in obtaining estimates for multivariate interpolation schemes; this is illustrated by an example involving generalized splines.
Madych, W.R, Potter, E.H
openaire   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Korovkin-type convergence results for multivariate Shepard formulae

Journal of Numerical Analysis and Approximation Theory, 2009
We present a new convergence proof for classic multivariate Shepard formulae within the context of Korovkin-type convergence results for positive operators on spaces of continuous real valued functions.
Oliver Nowak
doaj   +2 more sources

Proceedings of the Workshop on Kernel Functions and Meshless Methods honoring the 65th birthday of Robert Schaback, held in Göttingen (Germany), 14−15 January 2011 [PDF]

Dolomites Research Notes on Approximation, 2011
ContentGerlind Plonka-HochPreface • page 2Martin D. BuhmannApproximation in Göttingen: some remarks on Robert Schaback's work on its theory and applications • pages 3−14Len Bos • Stefano De Marchi • Alvise Sommariva • Marco VianelloOn multivariate ...
Martin Buhmann, Stefano De Marchi, Gerlind Plonka-Hoch   +2 more
doaj  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source