Results 81 to 90 of about 749,938 (278)
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Spreadsheets in Education, 2014 The economic valuation of complex financial contracts is often done using Monte-Carlo simulation. We show how to implement this approach using Excel. We discuss Monte-Carlo evaluation for standard single asset European options and then demonstrate how ...
Timothy J Kyng, Otto Konstandatos
doaj
Revstat Statistical Journal, 2010 We propose improvements under squared error loss of the minimum risk equivariant and the linear minimax estimators for estimating the location parameter θ of a p-variate spherically symmetric distribution, with θ restricted to a ball of radius m ...
Éric Marchand +1 more
doaj +1 more source
Missing covariates in logistic regression, estimation and distribution selection. [PDF]
We derive explicit formulae for estimation in logistic regression models where some of the covariates are missing. Our approach allows for modeling the distribution of the missing covariates either as a multivariate normal or multivariate t-distribution.
Claeskens, Gerda, Consentino, Fabrizio
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Advanced Science, EarlyView.A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong +7 more
wiley +1 more source
The affine equivariant sign covariance matrix: asymptotic behavior and efficiencies. [PDF]
We consider the affine equivariant sign covariance matrix (SCM) introduced by Visuri et al. (J. Statist. Plann. Inference 91 (2000) 557). The population SCM is shown to be proportional to the inverse of the regular covariance matrix. The eigenvectors and
Croux, Christophe, Oja, H, Ollila, E
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PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
On the noncentral distribution of the ratio of the extreme roots of wishart matrix
International Journal of Mathematics and Mathematical Sciences, 1981 The distribution of the ratio of the extreme latent roots of the Wishart matrix is useful in testing the sphericity hypothesis for a multivariate normal population.
V. B. Waikar
doaj +1 more source
Inhomogeneous Dependency Modelling with Time Varying Copulae [PDF]
Measuring dependence in a multivariate time series is tantamount to modelling its dynamic structure in space and time. In the context of a multivariate normally distributed time series, the evolution of the covariance (or correlation) matrix over time ...
Ekaterina Ignatieva +3 more
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Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source