Advanced Functional Materials, EarlyView.Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik +8 more
wiley +1 more source
1H NMR Combined with Multivariate Statistics for Discrimination of Female and Male Flower Buds of Populus tomentosa. [PDF]
Molecules, 2021 Xu B, Wu C, Li Z, Song P, Chao Z.
europepmc +1 more source
Advanced Functional Materials, EarlyView.Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro +25 more
wiley +1 more source
Similarity assessment by multivariate statistics method based on the distance between biosimilar and originator. [PDF]
Bioresour Bioprocess, 2021 Xu J +5 more
europepmc +1 more source
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Advanced Healthcare Materials, EarlyView.This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang +16 more
wiley +1 more source
Combining the multivariate statistics and dual stable isotopes methods for nitrogen source identification in coastal rivers of Hangzhou Bay, China. [PDF]
Environ Sci Pollut Res Int, 2022 Zhou J +6 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco +7 more
wiley +1 more source
Facial Expressions of Horses Using Weighted Multivariate Statistics for Assessment of Subtle Local Pain Induced by Polylactide-Based Polymers Implanted Subcutaneously. [PDF]
Animals (Basel), 2022 Carvalho JRG +8 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.A microfluidic device with magnetic microposts was used to assess platelet mechanobiology. The oscillatory actuation of posts with embedded iron particles was dampened by the dynamic stiffening of the platelet‐rich plugs. This stiffening process increased with applied load, but inhibiting platelet activation (ASA) or myosin contractility (blebbistatin)
Nikita Taparia +4 more
wiley +1 more source
Multivariate Statistics, Mineralogy, and Radiological Hazards Assessment Due to the Natural Radioactivity Content in Pyroclastic Products from Mt. Etna, Sicily, Southern Italy. [PDF]
Int J Environ Res Public Health, 2022 Caridi F +13 more
europepmc +1 more source