Results 211 to 220 of about 18,244,857 (290)

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

open access: yesArthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki   +8 more
wiley   +1 more source

Principal Component‐Based Classification of Blazar Candidates of Uncertain Type in the 4FGL/LAT

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT We adopted principal component analysis (PCA), linear discriminant analysis (LDA), and support vector machines (SVM), to study classification for a sample of 2708 Fermi blazars: 1142 BL Lac objects (BLLs), 759 flat spectrum radio quasars (FSRQs), and 807 blazar candidates of uncertain type (BCUs).
Wen‐Xin Yang   +13 more
wiley   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said   +13 more
wiley   +1 more source

How curriculum modifications shape educational pathways: Evidence from linked administrative data in Switzerland

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The increasing heterogeneity of learning needs and preconditions in inclusive mainstream classrooms entails that not all learners are equally able to meet the regular learning objectives. In response, various integrative measures have been implemented to tailor instruction to students' individual needs.
Robin Benz   +2 more
wiley   +1 more source

Comparative analysis of CNN-LSTM and CNN-BiLSTM hybrid deep learning models for solar radiation prediction. [PDF]

open access: yesSci Rep
Raghav YY   +6 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

open access: yesBiotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga   +2 more
wiley   +1 more source

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