Results 131 to 140 of about 964,068 (308)

lncRNA LINC02323 predicts adverse neoadjuvant chemotherapy outcomes of gastric cancer patients and regulates cell sensitivity to 5-fluorouracil by negatively modulating miR-139-3p

open access: yesAnnals of Medicine
Background/Objective Drug resistance is a challenging problem in the clinical chemotherapy of gastric cancer. Identification of predictive biomarkers for chemotherapy outcomes could improve therapeutic efficacy and patient prognosis.
Zexu Chen   +4 more
doaj   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

open access: yesAdvanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang   +7 more
wiley   +1 more source

Development of outbound trade in municipal areas

open access: yesRussian Journal of Management
The article considers the features of the placement of trading facilities and the organization of traveling trade, shows its significance for sparsely populated rural settlements. It is relevant to use the historical experience of organizing traveling trade in the northern regions and in cooperative trade.
openaire   +1 more source

The development of downtown Winnipeg : historical perspectives on decline and revitalization [PDF]

open access: yes, 1984
Report: viii, 200 p., maps, digital fileThis report examines the ancestry of some of the current major policy concerns relating to Winnipeg's downtown area.
Fenton, Robert, Lyon, Deborah
core  

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

open access: yesAdvanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang   +10 more
wiley   +1 more source

MUNICIPAL ASPECT OF INDUSTRIAL POLICY [PDF]

open access: yesЭкономика региона, 2007
Features of formation of industrial policy at a municipal level are considered, the role citibased enterprises in development of municipal economy is established.
A.M. Trapeznikov
doaj  

Fiscal Federalism and Public Service Provision in Canada [PDF]

open access: yes
This paper provides a general overview of the allocation of revenues and expenditures across levels of governments in Canada and discusses how public services in specific areas are financed and delivered.
Jean-François Tremblay
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

open access: yesAdvanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu   +11 more
wiley   +1 more source

Behavior of the main functional indicators of the municipal intensive care area in Los Palacios municipality

open access: yesRevista de Ciencias Médicas de Pinar del Río, 2018
Introduction: the implementation of municipal intensive care areas and their location at the primary health care level has favored the management of critical patients.
Magaly Gort Hernández   +2 more
doaj  

Optimization of Loop-Mediated Isothermal Amplification for Avian Influenza Detection

open access: yesAnimals
Avian influenza viruses (AIV) cause severe economic losses in poultry production and pose zoonotic threats, necessitating rapid, field-deployable diagnostics.
Anastasia Glazunova   +8 more
doaj   +1 more source

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