Results 111 to 120 of about 242,673 (315)

Local governments in the wake of demographic change: evidence from German municipalities [PDF]

open access: yes
German municipalities are expected to suffer from intense demographic changes in the upcoming decades; not only in the form of population losses, but also through a changing demographic structure (i.e.
Heinemann, Friedrich   +2 more
core  

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

open access: yesAdvanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu   +16 more
wiley   +1 more source

On Local Government Spending and Taxation Behaviour - Effect of population size and economic condition [PDF]

open access: yes
This paper examines the Granger-causality between total expenditures, own source revenues, grants received from state and long term loans for 12 subgroups of Finnish municipalities.
Antti Moisio
core  

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

open access: yesAdvanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang   +16 more
wiley   +1 more source

Locally Provided Public Schooling in Brazilian Municipalities [PDF]

open access: yes
The objective of this paper is to assess the demand for public schooling in the Brazilian municipalities within a median voter framework. The quantile regression and spatial techniques proved to be useful to account for the spatial and marginal effects ...
Maria da Conceição Sampaio e Sousa
core  

Commemorating Foreign Partnerships in the Landscape of Polish Municipalities: The Case of the Gniezno District

open access: yesStudia Regionalne i Lokalne
The aim of the article is to depict the issue of commemorating foreign partnerships of municipalities present in the public space. The municipalities of the Gniezno district were selected as a case study.
Igor Ksenicz
doaj   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

open access: yesAdvanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu   +17 more
wiley   +1 more source

Strategic Interaction in Local Fiscal Policy: Evidence from Portuguese Municipalities [PDF]

open access: yes
This paper aims at testing the degree of interaction between Portuguese municipalities’ expenditure levels by estimating a dynamic panel model, based on jurisdictional reaction functions.
Linda Gonçalves Veiga   +2 more
core  

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

open access: yesAdvanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang   +11 more
wiley   +1 more source

Explaining budgetary indiscipline: evidence from spanish municipalities [PDF]

open access: yes
The quest for political support drives to upward deviations from forecasted public deficits when i) budget procedures are soft, ii) breaking promises involving higher expenditures and lower taxes is costly in political terms, and iii) ex–post control by ...
Santiago Lago-Peñas   +1 more
core  

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