Results 131 to 140 of about 664,031 (315)

Polish Sceptics and Czech Optimists: Perception of the Development within Euroregion Beskydy

open access: yesTér és Társadalom
The openness of space is one of the fundamental ideas behind the existence of the European Union. The benefits arising from this should outweigh the disadvantages associated with it.
Suchaček Jan, Urminský Jaroslav
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source

Monitoring and evaluation strategies: lessons learned from COVID-19 pandemic

open access: yesCogent Business & Management
The COVID-19 pandemic presents unique challenges that necessitate a new approach to monitoring and evaluation (M&E) in local government. The culture of poor performance, high incompetency levels among employees and financial mismanagement – widely ...
Babalo Yekani   +2 more
doaj   +1 more source

Using Spatial Econometrics to Analyze Local Growth in Sweden [PDF]

open access: yes
This paper investigates factors that determine the average income growth and net migration rates in Swedish municipalities during the period 1981 to 1999.
Johan Lundberg
core  

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

Tax interaction dynamics among Belgian municipalities, 1984-1997 [PDF]

open access: yes
The purpose of this paper is to test econometrically the existence of fiscal interactions between Belgian municipalities. At the time of writing, the motivation was to provide scientific support to the lively debate on fiscal competition that took place ...
Henry, TULKENS   +2 more
core  

Municipal Health Plans: Gilded Benefits From a Bygone Era [PDF]

open access: yes, 2011
Compares the premiums, deductibles, and co-pays for office visits, prescription drugs, high-tech imaging, outpatient surgery, and hospital admissions of fourteen municipalities' employee health plans with those of other public and private ...
Robert Carey
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

open access: yesAdvanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei   +11 more
wiley   +1 more source

The impact of central places on spatial spending patterns: evidence from Flemish local government cultural expenditures [PDF]

open access: yes
Governments often see it as their responsibility to support cultural life and at times spend a significant amount of resources in the pursuit of this goal. The present paper analyses whether and how municipalities influence each other in this decision to
Geys, Benny   +2 more
core  

Local Government Website Updated Report Card [PDF]

open access: yes, 2018
In 2017, the Buffalo Niagara Coalition for Open Government evaluated the websites of sixteen municipalities in Erie and Niagara ...
Buffalo Niagara Coalition for Open Government
core   +1 more source

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