Results 141 to 150 of about 242,673 (315)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Agglomeration, accessibility and industrial location: evidence from spanish municipalities [PDF]

This paper deals with the location decisions of manufacturing firms in Spain. We analyse how agglomeration economies and transport accessibility influence the location decisions of firms at municipality level and in three industries.
Josep-Maria Arauzo-Carod, Ángel Alañón-Pardo   +1 more
core  

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

URBAN PLANNING WITH THE AID OF FACTOR ANALYSIS APPROACH: THE CASE OF ISFAHAN MUNICIPALITY [PDF]

Nowadays municipalities play an important role in offering urban services to the citizens. To investigate performance of regional municipalities, different data on living situation must be considered. Thus, we face a multivariate analysis.
Iman NOSOOHI, Ali ZEINAL - HAMADANI
core  

Polish Sceptics and Czech Optimists: Perception of the Development within Euroregion Beskydy

Tér és Társadalom
The openness of space is one of the fundamental ideas behind the existence of the European Union. The benefits arising from this should outweigh the disadvantages associated with it.
Suchaček Jan, Urminský Jaroslav
doaj   +1 more source

Canadian Municipal Infrastructure Solutions : A Practical Technical Guide for Municipalities, by Municipalities

, 1998
An analysis of available data indicates Canadian municipalities could save in excess of $1 billion per year (more than 10% of their present annual expenditure) or $33 per capita/per year by adopting best practices and proven technologies for infrastructure construction, maintenance and rehabilitation.
Félio, G. Y., Mareschal, R.
openaire   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Self-Serving Mayors and Local Government Consolidations in Japan [PDF]

This paper investigates local government consolidations with a focus on public choice aspects in the decision-making. Politicians could lose future payoffs if their locality merges with a larger counterpart, and they may sabotage the merger process.
Akihiko Kawaura
core  

Monitoring and evaluation strategies: lessons learned from COVID-19 pandemic

Cogent Business & Management
The COVID-19 pandemic presents unique challenges that necessitate a new approach to monitoring and evaluation (M&E) in local government. The culture of poor performance, high incompetency levels among employees and financial mismanagement – widely ...
Babalo Yekani, Bethuel Sibongiseni Ngcamu, Sareesha Pillay   +2 more
doaj   +1 more source