New distribution records of Aedes aegypti (Linnaeus), Aedes mediovittatus (Coquillett), and Toxorhynchites portoricensis (Röder) (Diptera: Culicidae) in Puerto Rico and their relevance to integrated vector management. [PDF]
J Med EntomolBae JS +12 more
europepmc +1 more source
Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
CAN GENDER QUOTAS BREAK DOWN NEGATIVE STEREOTYPES? EVIDENCE FROM CHANGES IN ELECTORAL RULES [PDF]
In this paper we analyse the effect of gender quotas on women involvement in political activity using a rich data set providing information on all Italian local administrators elected from 1985 to 2007.
Maria De Paola +2 more
core
Exercise modalities and outcome measures used in older adults after hip fracture with or without signs of cognitive impairment: a national cross-sectional e-survey of 90 out of 98 municipalities in Denmark. [PDF]
J Rehabil MedOvergaard JA +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu +7 more
wiley +1 more source
Bailouts in Costa Rica as a Result of Government Centralization and Discretionary Transfers [PDF]
This paper investigates the inter-relation between the central government and the municipalities in Costa Rica. It examines episodes in which the central government has bailed out the local governments from their obligations.
Alexander Monge-Naranjo +2 more
core
Advanced Science, EarlyView.Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang +14 more
wiley +1 more source
The Nexø Method-Clinical Evidence for the Paradigm Shift in Caries Management for Children and Adolescents in Denmark Being Cost-Effective. [PDF]
Children (Basel)Ekstrand KR, Christiansen MEC.
europepmc +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source