Results 21 to 30 of about 40,987 (253)
Advanced Science, EarlyView.Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu +13 more
wiley +1 more source
THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome
Advanced Science, EarlyView.The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong +16 more
wiley +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source
Mural Internacional, 2020 Mural Internacional volume 11, 2020 O ano de 2020 tornou-se um período particularmente desafiador e a compreensão das relações internacionais, de modo geral, nunca pareceu tão premente.
Mural Internacional
doaj +1 more source
Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model
Animal Models and Experimental Medicine, EarlyView.We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin +7 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli +6 more
wiley +1 more source
Reflections of Feminism in Contemporary Mural Painting between Occidental and Oriental societies
ARCHive-SR, 2017 Feminism as a global movement was and is still working on achieving women rights & liberation in different ways and by using different tools. Art in general and mural painting as a public art in specific, are very eloquent tools to help present feminist ...
Zeinab Nour
doaj +1 more source
Circulation, 2006 A 64-year-old man with type 2 diabetes mellitus was admitted to our emergency department for a 12-hour history of waxing and waning chest pain. During the first hour of observation, he complained about a new episode of chest pain accompanied by ST elevation in leads V2 and V3.
Coli, Stefano +4 more
openaire +2 more sources
Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope
Animal Research and One Health, EarlyView.FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad +7 more
wiley +1 more source
Mural Internacional, 2011 DOI: http://dx.doi.org/10.12957/rmi.2011 ...
Mural Internacional
doaj +1 more source