Results 41 to 50 of about 79,529 (297)

Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1

Nature Communications
Mural cells are central to vascular integrity and function. In this study, we demonstrate the innovative use of the transcription factor NKX3.1 to guide the differentiation of human induced pluripotent stem cells into mural progenitor cells (iMPCs).
Umji Lee, Yadong Zhang, Yonglin Zhu, A. C. Luo, Liyan Gong, Daniel M Tremmel, Yunhye Kim, V. S. Villarreal, Xi Wang, Ruei-Zeng Lin, Miao Cui, Minglin Ma, Ke Yuan, Kai Wang, Kaifu Chen, Juan M. Melero-Martin   +15 more
semanticscholar   +1 more source

Conserved and context-dependent roles for Pdgfrb signaling during zebrafish vascular mural cell development

bioRxiv, 2021
Platelet derived growth factor beta and its receptor, Pdgfrb, play essential roles in the development of vascular mural cells, including pericytes and vascular smooth muscle.
Koji Ando, Yu-Huan Shih, Lwaki Ebarasi, Ann S. Grosse, Daneal Portman, Ayano Chiba, K. Mattonet, C. Gerri, D. Stainier, N. Mochizuki, S. Fukuhara, C. Betsholtz, N. Lawson   +12 more
semanticscholar   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Notch3 directs differentiation of brain mural cells from human pluripotent stem cell–derived neural crest

Science Advances
Brain mural cells regulate development and function of the blood-brain barrier and control blood flow. Existing in vitro models of human brain mural cells have low expression of key mural cell genes, including NOTCH3. Thus, we asked whether activation of
Benjamin D. Gastfriend, M. Snyder, Hope E. Holt, R. Daneman, S. Palecek, Eric V. Shusta   +5 more
semanticscholar   +1 more source

Integrative analysis of the human brain mural cell transcriptome

Journal of Cerebral Blood Flow and Metabolism, 2021
Brain mural cells, including pericytes and vascular smooth muscle cells, are important for vascular development, blood-brain barrier function, and neurovascular coupling, but the molecular characteristics of human brain mural cells are incompletely ...
Benjamin D. Gastfriend, Koji L. Foreman, Moriah E Katt, S. Palecek, Eric V. Shusta   +4 more
semanticscholar   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Apresentação / Presentation

Mural Internacional, 2010
DOI: http://dx.doi.org/10.12957/rmi.2010 ...
Mural Internacional
doaj   +3 more sources

Editorial Dossiê ABRI | Dossier Editorial ABRI

Mural Internacional, 2019
A Área Temática "Ensino, Pesquisa e Extensão" compõe o quadro dos grupos de pesquisa permanentes da Associação Brasileira de Relações Internacionais (ABRI).
Mural Internacional
doaj   +1 more source

Ancient mural restoration based on a modified generative adversarial network

Heritage Science, 2020
How to effectively protect ancient murals has become an urgent and important problem. Digital image processing developments have made it possible to repair damaged murals to a certain extent.
Jianfang Cao, Zi-Bang Zhang, Aidi Zhao, Hong-Yan Cui, Qi Zhang   +4 more
semanticscholar   +1 more source

Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration

Cells, 2021
Mural cells collectively refer to the smooth muscle cells and pericytes of the vasculature. This heterogenous population of cells play a crucial role in the regulation of blood pressure, distribution, and the structural integrity of the vascular wall. As
A. Lin, Niridu Peiris, H. Dhaliwal, M. Hakim, Wei-Zhen Li, S. Ganesh, Y. Ramaswamy, Sanjay Patel, A. Misra   +8 more
semanticscholar   +1 more source