Results 171 to 180 of about 8,976 (288)

Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in <i>Caulobacter crescentus</i>. [PDF]

Elife
Richter P, Merz A, Biboy J, Paczia N, Glatter T, Ng J, Vollmer W, Thanbichler M.   +7 more
europepmc   +1 more source

Recent progress on stimuli‐responsive chitosan‐based biomaterials as drug carriers

Interdisciplinary Medicine, EarlyView.
This review discusses the recent progress in chitosan‐based drug delivery systems that respond to pH, redox, enzymes, reactive oxygen species, and combined stimuli. It examines design strategies, key mechanisms, and therapeutic applications, and also addresses current challenges while suggesting future approaches to enhance clinical translation and ...
Changlu Xu, Yi‐Tung Lu, Bin Yang, Zhi Li, Kui Zeng   +4 more
wiley   +1 more source

Beyond Direct Fibrinolysis: Novel Approaches to Thrombolysis. [PDF]

Pharmaceuticals (Basel)
Shibeko AM, Nikitin NS, Podoplelova NA, Manuvera VA, Lazarev VN.   +4 more
europepmc   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Phage endolysins as alternative antimicrobials: mechanisms, clinical progress, and emerging resistance frameworks. [PDF]

Front Microbiol
Qian H, Zheng Y.
europepmc   +1 more source

Using generalized quantitative structure–property relationship (QSPR) models to predict host cell protein retention in ion‐exchange chromatography

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Selecting an optimal chromatography resin during biopharmaceutical downstream process development is a great challenge. This is especially the case for recombinant subunit vaccines, where product properties vary greatly and recovery often involves cell lysis, which yields a complex mixture of different host cell materials. Host cell
Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke E Klijn, Marcel Ottens   +4 more
wiley   +1 more source

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

Synergistic Impacts of Co‐Exposure to Microplastics and Vibrio harveyi on the Immune and Stress Responses of the Big‐Belly Seahorse Hippocampus abdominalis

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Synergistic effects of microplastic and Vibrio harveyi co‐exposure on big‐belly seahorse (Hippocampus abdominalis). Seahorses were exposed to microplastics (50 beads/L of 0.2 μm SMP and 1.0 μm LMP) and injected with V. harveyi (1 × 103 CFU/mL).
Jin A Kim, Min‐Min Jung, Seong Don Hwang, Jun‐Hwan Kim, Cheol Young Choi   +4 more
wiley   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source

Research note: Application and validation of RP-HPLC for quantifying ovomucoid, lysozyme, ovotransferrin, and ovalbumin in commercial pasteurized egg white. [PDF]

Poult Sci
Sousa I, Visentin E, Sabbadin S, Pozza M, Birolo M, De Marchi M, Niero G.   +6 more
europepmc   +1 more source