Results 71 to 80 of about 8,976 (288)

TLR4 Agonist Combined with Trivalent Protein JointS of Streptococcus suis Provides Immunological Protection in Animals

Vaccines, 2021
Streptococcus suis (S. suis) serotype 2 (SS2) is the causative agent of swine streptococcosis and can cause severe diseases in both pigs and humans. Although the traditional inactive vaccine can protect pigs from SS2 infection, novel vaccine candidates ...
Zhaofei Wang, Mengting Guo, Licheng Kong, Ya Gao, Jingjiao Ma, Yuqiang Cheng, Henan Wang, Yaxian Yan, Jianhe Sun   +8 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media

BMC Infectious Diseases, 2008
Background Lysozyme is an antimicrobial innate immune molecule degrading peptidoglycan of the bacterial cell wall. Lysozyme shows the ubiquitous expression in wide varieties of species and tissues including the tubotympanum of mammals.
Woo Jeong-Im, Pan Huiqi, Takeshita Tamotsu, Lee Haa-Yung, Moon Sung K, Shimada Jun, Gellibolian Robert, Yamanaka Noboru, Lim David J   +8 more
doaj   +1 more source

The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers. [PDF]

, 2017
Peptidoglycan is a giant molecule that forms the cell wall that surrounds bacterial cells. It is composed of alternating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) residues connected by β-(1,4)-glycosidic bonds and cross-linked with short ...
Anderson, Andrejašič, Archer, Bai, Berger, Berman, Biswas, Blake, Blaser, Bublitz, Büttner, Dantes, Davies, Eschenfeldt, Gardete, Gille, Guerrero, Hanberger, Hashimoto, Heilmann, Helland, Hiramatsu, Ho, Holm, Johnson, Joti, Kantoci, Keglevic, Kelly, Kuroki, Lombard, Lowy, Matthews, Matthews, Merritt, Minor, Murshudov, Nashed, Nunes, Odintsov, Oshida, Otwinowski, Pražnikar, Shindyalov, Studier, Sugai, Turk, Varrone, Vincent, Vocadlo, Weaver, Wheeler, Xia, Ye, Zetola, Zoll   +55 more
core   +4 more sources

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source

Pre-absorbed immunoproteomics: a novel method for the detection of Streptococcus suis surface proteins. [PDF]

PLoS ONE, 2011
Streptococcus suis serotype 2 (SS2) is a zoonotic pathogen that can cause infections in pigs and humans. Bacterial surface proteins are often investigated as potential vaccine candidates and biomarkers of virulence.
Wei Zhang, Guangjin Liu, Fang Tang, Jing Shao, Yan Lu, Yinli Bao, Huochun Yao, Chengping Lu   +7 more
doaj   +1 more source

Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications

Advanced Materials, EarlyView.
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa, Paolo Blesio, Marcial Fernandez‐Castro, Lisa Almonte, Maxence Fernandez, Mantas Liutkus, Perumal Pandurangan, Carlos Sabater, Aitor Villaverde, Manuel Melle‐Franco, Nurit Ashkenasy, Felipe Jiménez‐Ángeles, M. Carmen Morant‐Miñana, M. Reyes Calvo, Aitziber L. Cortajarena   +14 more
wiley   +1 more source

Lineage and Virulence of Streptococcus suis Serotype 2 Isolates from North America

Emerging Infectious Diseases, 2011
We performed multilocus sequence typing of 64 North American Streptococcus suis serotype 2 porcine isolates. Strains were sequence type (ST) 28 (51%), ST25 (44%), and ST1 (5%).
Nahuel Fittipaldi, Jiangu Xu, Sonia Lacouture, Prasit Tharavichitkul, Makoto Osaki, Tsutomu Sekizaki, Daisuke Takamatsu, Marcelo Gottschalk   +7 more
doaj   +1 more source

Distribution and composition of the lysis cassette of Lactococcus lactis phages and functional analysis of bacteriophage ul36 holin [PDF]

, 2017
The bacteriophage lysis cassette, which comprises a lysin and a holin gene, was analyzed in 18 Lactococcus lactis phages. A muramidase motif was found in the lysins of c2-like phages, while an amidase motif was observed in the lysins of 936-like phages ...
Labrie, Steve, Loessner, Martin J., Moineau, Sylvain, Vukov, Nataša   +3 more
core  

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source