Results 111 to 120 of about 72,711 (261)

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

Glia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri, Savannah G. Sims, Jessica A. Herstine, Alicia Meyer, Micah J. Marshall, Ishrat Jahan, Subhodip Adhicary, Allison M. Bradbury, Gordon P. Meares   +8 more
wiley   +1 more source

Phosphoryl guanidine oligonucleotides as primers for RNA-dependent DNA synthesis using murine leukemia virus reverse transcriptase. [PDF]

Vavilovskii Zhurnal Genet Selektsii, 2022
Dyudeeva ES, Pyshnaya IA.
europepmc   +1 more source

Development of Murine Leukemia Virus Integrase-Derived Peptides That Bind Brd4 Extra-Terminal Domain as Candidates for Suppression of Acute Myeloid Leukemia. [PDF]

ACS Pharmacol Transl Sci, 2021
Xing E, Surendranathan N, Kong X, Cyberski N, Garcia JD, Cheng X, Sharma A, Li PK, Larue RC.   +8 more
europepmc   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine, EarlyView.
This review highlights the applications of advanced single‐cell RNA sequencing (scRNA‐seq) technologies in tumor immunology. It summarizes representative scRNA‐seq methods according to technical principles, with a focus on single‐cell T cell receptor sequencing. This review also discusses how scRNA‐seq is used to construct immune cell atlases of tumors,
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
wiley   +1 more source

A Novel In Vitro Host−Pathogen Model for Felis catus and Sporothrix Zoonotic Species Investigation

Journal of Basic Microbiology, EarlyView.
ABSTRACT Hyperendemic zoonotic sporotrichosis, attributed to Sporothrix brasiliensis, presents a significant public health challenge in Brazil. Cats exhibit severe symptoms and high fungal loads, though their susceptibility is unclear. Sporothrix schenckii can also cause feline disease, primarily seen in Asia.
Gabriele Barros Mothé, Nathália Faria Reis, Emylli Dias Virginio, Miguel Angelo da Silva Medeiros, Adriany Lucas dos Santos, Júlia Andrade de Castro Rodrigues, Ricardo Luiz Dantas Machado, Gutemberg Gomes Alves, Nathália Curty de Andrade, Leila Maria Lopes‐Bezerra, Andréa Regina de Souza Baptista   +10 more
wiley   +1 more source

Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) in phospholipid membranes promote α‐synuclein binding, aggregation, and toxicity ...
Finula I. Isik, YuHong Fu, Russell Pickford, Qi Cheng, Yue Yang, Simon J.G. Lewis, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim   +8 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

DHX15 inhibits mouse APOBEC3 deamination.

PLoS Pathogens
APOBEC3 family proteins are critical host factors that counteract and prevent the replication of retroviruses and other viruses through cytidine deamination.
Wenming Zhao, Ayan Modak, Susan R Ross
doaj   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source