Results 221 to 230 of about 72,711 (261)

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation

MedComm, Volume 6, Issue 8, August 2025.
This review discussed the signaling pathways of Toll‐like receptors in tumors and their antitumor or protumor regulatory effects in diverse tumors. We also paid attention to the application of Toll‐like receptors in clinical treatment and summarized the clinical trial situation in recent years.
Nueraili Maihemuti, Yueli Shi, Kaiyue Zhang, Xinyuan Jiang, Jiahe Chu, Yun Xu, Zhiyong Xu, Kai Wang   +7 more
wiley   +1 more source

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.
Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley   +1 more source

Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection. [PDF]

J Virol, 2017
Opazo T, Garcés A, Tapia D, Barraza F, Bravo A, Schwenke T, Cancino J, Arriagada G.   +7 more
europepmc   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, Volume 157, Issue 2, Page 371-383, 15 July 2025.
What's new? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Tetherin Inhibits Cell-Free Virus Dissemination and Retards Murine Leukemia Virus Pathogenesis. [PDF]

J Virol, 2017
Liberatore RA, Mastrocola EJ, Powell C, Bieniasz PD.   +3 more
europepmc   +1 more source

Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells. [PDF]

J Virol, 2017
Wang GZ, Goff SP.
europepmc   +1 more source

Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study. [PDF]

Int J Mol Sci, 2019
Chen Q, Wang Y, Shi S, Li K, Zhang L, Gao J.   +5 more
europepmc   +1 more source

Murine leukemia virus morphogenesis: cleavage of P70 in vitro can be accompanied by a shift from a concentrically coiled internal strand ("immature") to a collapsed ("mature") form of the virus core.

, 1977
Yoshiyuki Yoshinaka, Ronald B. Luftig
openalex   +1 more source

Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply. [PDF]

Clin Microbiol Rev, 2016
Johnson AD, Cohn CS.
europepmc   +1 more source

Correction to “Comparison of Seven CD19 CAR Designs in Engineering NK Cells for Enhancing Anti‐Tumour Activity”

Cell Proliferation, EarlyView.
wiley   +1 more source