Advances in Virology, 2011 Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as ...
Oya Cingöz, John M. Coffin
doaj +1 more source
Frequent Infection of Human Cancer Xenografts with Murine Endogenous Retroviruses in Vivo
Viruses, 2015 Infection of human cancer xenografts in mice with murine leukemia viruses (MLVs) is a long-standing observation, but the likelihood of infection in vivo and its biological consequences are poorly understood.
Asif Naseer +10 more
doaj +1 more source
The saga of XMRV: a virus that infects human cells but is not a human virus
Emerging Microbes and Infections, 2014 Xenotropic murine leukemia virus-related virus (XMRV) was discovered in 2006 in a search for a viral etiology of human prostate cancer (PC). Substantial interest in XMRV as a potentially new pathogenic human retrovirus was driven by reports that XMRV ...
Maribel Arias, Hung Fan
doaj +1 more source
Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1. [PDF]
PLoS ONE, 2012 The 22Rv1 cell line is widely used for prostate cancer research and other studies throughout the world. These cells were established from a human prostate tumor, CWR22, that was serially passaged in nude mice and selected for androgen independence.
Jaydip Das Gupta +7 more
doaj +1 more source
No association between XMRV or related gammaretroviruses in Australian prostate cancer patients
Virology Journal, 2013 Background Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with prostate cancer (PC) and chronic fatigue syndrome (CFS).
Rezaei Simin D +4 more
doaj +1 more source
Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. [PDF]
PLoS Genetics, 2008 Intrinsic immunity relies on specific recognition of viral epitopes to mount a cell-autonomous defense against viral infections. Viral recognition determinants in intrinsic immunity genes are expected to evolve rapidly as host genes adapt to changing ...
Julie A Kerns +2 more
doaj +1 more source
Characterization of Leukemia-Inducing Genes Using a Proto-Oncogene/Homeobox Gene Retroviral Human cDNA Library in a Mouse In Vivo Model. [PDF]
PLoS ONE, 2015 The purpose of this research is to develop a method to screen a large number of potential driver mutations of acute myeloid leukemia (AML) using a retroviral cDNA library and murine bone marrow transduction-transplantation system.
Su Hwa Jang, Sohyun Lee, Hee Yong Chung
doaj +1 more source
Characterizationof Murine Leukemia Virus Restriction inMammals [PDF]
Journal of Virology, 2003 ABSTRACT Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human ...
Caroline, Besnier +6 more
openaire +2 more sources
Infectious viral DNA of murine leukemia virus. [PDF]
Proceedings of the National Academy of Sciences, 1975 A fraction of the unintegrated viral DNA that appears early after infection of mouse cells by Moloney leukemia virus is infectious. The infectivity could be deomonstrated by an XC plaque assay of the cells exposed to DNA co-precipitated with calcium phosphate.
D. Smotkin +3 more
openaire +3 more sources
The Immunoproteasome Is Expressed but Dispensable for a Leukemia Infected Cell Vaccine
VaccinesBackground/Objectives: Leukemia is associated with high recurrence rates and cancer vaccines are emerging as a promising immunotherapy against the disease.
Delphine Béland +5 more
doaj +1 more source