Results 181 to 190 of about 17,657,887 (204)

Musashi 2 in hematopoiesis

Current Opinion in Hematology, 2012
Recent work has shown that the Musashi 2 (Msi2) gene plays important roles in normal and malignant hematopoiesis. Here, we give an overview on the role of Msi2 in the regulation and function of primitive hematopoietic cells as well as in leukaemic progression.
Luisa, de Andrés-Aguayo, Florencio, Varas, Thomas, Graf   +2 more
openaire   +2 more sources

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

2023
Abstract Lung cancer is one of the most common types of cancers worldwide. Non-small cell lung cancer (NSCLC), typically caused by KRAS and TP53 driver mutations, represents the majority of all new lung cancer diagnoses.
Igor Bychkov, Alexander Deneka, Iuliia Topchu, Rajendra P. Pangeni, Christopher Lengner, John Karanicolas, Erica A. Golemis, Petr Makhov, Yanis Boumber   +8 more
openaire   +3 more sources

Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation [PDF]

Journal of Biological Chemistry, 2019
The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation.
Melanie C Macnicol, Stephanie D Byrum, Samuel G Mackintosh   +2 more
exaly   +2 more sources

The Musashi 2 mRNA Expression in the Course of CML.

Blood, 2012
Abstract Abstract 2552 The Musashi (MSI) gene family members, MSI1 and MSI2, represent an evolutionarily conserved family of RNA-binding proteins that regulate mRNA translation through binding in their N-termini. High levels of MSI2 protein are associated with increased cell proliferation, decreased cell maturation, more ...
Sylvie Nadvornikova, Marketa Zackova, Tereza Lopotova, Hana Klamova, Jana Moravcova   +4 more
openaire   +1 more source

Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution

FEBS Letters, 2006
Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1.
Hiroshi Nagata, Yasutada Akiba, Hidekazu Suzuki   +2 more
exaly   +2 more sources

Identification of a putative intestinal stem cell and early lineage marker; musashi-1

Differentiation, 2003
There are few reliable markers for adult stem cells and none for those of the intestinal epithelium. Previously, indirect experimental approaches have predicted stem cell position and numbers.
Christopher S Potten, Catherine Booth, Gérard Brady   +2 more
exaly   +2 more sources

PLAG1 and USF2 Regulate Primitive Hematopoietic Expression of Musashi-2

Blood, 2015
Abstract The Musashi-2 (MSI2) RNA binding protein is now recognized as a key regulator of hematopoietic stem cells (HSCs). Its expression is most elevated in the primitive HSC compartment and progressively decreases with differentiation.
Muluken S Belew, Stefan Rentas, Laura de Rooij, Kristin J Hope   +3 more
openaire   +1 more source

Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice

Blood, 2011
Abstract We used a retroviral integration screen to search for novel genes that regulate HSC function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA-binding protein that can act as a translational inhibitor.
Luisa, de Andrés-Aguayo, Florencio, Varas, Eric M, Kallin, José F, Infante, Wolfgang, Wurst, Thomas, Floss, Thomas, Graf   +6 more
openaire   +2 more sources

Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation

Cancer Letters, 2017
Accumulating evidence suggests that cancer stem cells (CSCs), a small subset of cancer cells, are responsible for tumor initiation, progression, relapse and metastasis. Musashi 2 (MSI2), a RNA-binding protein, was proposed to be a potent oncogene playing key roles in myeloid leukemia and gastrointestinal malignancies.
Tian, Fang, Hongwei, Lv, Fuquan, Wu, Changzheng, Wang, Ting, Li, Guishuai, Lv, Liang, Tang, Linna, Guo, Shanhua, Tang, Dan, Cao, Mengchao, Wu, Wen, Yang, Hongyang, Wang   +12 more
openaire   +2 more sources

Cooperation of Musashi‐2, Numb, MDM2, and P53 in drug resistance and malignant biology of pancreatic cancer

The FASEB Journal, 2017
ABSTRACT Our earlier work showed that Musashi (MSI)‐2 promoted the development of pancreatic cancer (PC) by down‐regulating Numb, which prevented murine double‐minute (MDM)‐2–mediated p53 ubiquitin degradation. Thus, we investigate the relationship among MSI2, Numb, MDM2, and p53 in PC in vitro
Weiwei, Sheng, Ming, Dong, Chuanping, Chen, Zixin, Wang, Yunwei, Li, Kewei, Wang, Yuji, Li, Jianping, Zhou   +7 more
openaire   +2 more sources