Results 161 to 170 of about 6,635 (196)
Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis [PDF]
International Journal of Molecular Sciences, 2022 The stem cell marker and RNA-binding protein Musashi-1 is overexpressed in endometriosis. Musashi-1-siRNA knockdown in Ishikawa cells altered the expression of stem cell related genes, such as OCT-4. To investigate the role of both human Musashi homologues (MSI-1 and MSI-2) in the pathogenesis of endometriosis, immortalized endometriotic 12-Z cells and
Theresa Strauß +2 more
exaly +9 more sources
Prognostic value of Musashi-1 in gliomas
Journal of Neuro-Oncology, 2013 The aim of this study was to investigate the prognostic value of the RNA-binding protein Musashi-1 in adult patients with primary gliomas. Musashi-1 has been suggested to be a cancer stem cell-related marker in gliomas, and high levels of Musashi-1 have been associated with high tumor grades and hence poor prognosis.
Rikke Hedegaard Dahlrot +2 more
exaly +5 more sources
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Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue
Andrologia, 2021MUSASHI (MSI) family plays the main role in the spermatogenesis process. The purpose of this study was the assessment of sperm MSI1 and MSI2, and sperm functional tests in infertile men (n = 30) with varicocele and fertile men (n = 30). Furthermore, MSI1 and MSI2 proteins were assessed in testicular tissue of azoospermic men (n = 9) as well as ...
Kianoush Dormiani +2 more
exaly +3 more sources
Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation [PDF]
Journal of Biological Chemistry, 2019 The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation.
Melanie C Macnicol +2 more
exaly +2 more sources
Molecular Neurobiology, 2022 Musashi RNA-binding proteins (MSIs) retain a pivotal role in stem cell maintenance, tumorigenesis, and nervous system development. Recently, we showed in C.
Pavlina Mastrandreas +2 more
exaly +2 more sources
Archives of Medical Research, 2023
While preliminary evidence points to pro-tumorigenic roles for the Musashi (MSI) RNA-binding proteins Musashi-1 (MSI1) and Musashi-2 (MSI2) in some breast cancer subtypes, no data exist for inflammatory breast cancer (IBC).MSI gene expression was quantified in IBC SUM149PT cells.
Nancy Adriana Espinoza-Sánchez +2 more
exaly +3 more sources
While preliminary evidence points to pro-tumorigenic roles for the Musashi (MSI) RNA-binding proteins Musashi-1 (MSI1) and Musashi-2 (MSI2) in some breast cancer subtypes, no data exist for inflammatory breast cancer (IBC).MSI gene expression was quantified in IBC SUM149PT cells.
Nancy Adriana Espinoza-Sánchez +2 more
exaly +3 more sources
Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution
FEBS Letters, 2006 Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1.
Hiroshi Nagata +2 more
exaly +2 more sources
Musashi Signaling in Stem Cells and Cancer
Annual Review of Cell and Developmental Biology, 2015How a single cell gives rise to an entire organism is one of biology's greatest mysteries. Within this process, stem cells play a key role by serving as seed cells capable of both self-renewal to sustain themselves as well as differentiation to generate the full diversity of mature cells and functional tissues.
Marcie Kritzik, Tannishtha Reya
exaly +3 more sources
Current Opinion in Hematology, 2012
Recent work has shown that the Musashi 2 (Msi2) gene plays important roles in normal and malignant hematopoiesis. Here, we give an overview on the role of Msi2 in the regulation and function of primitive hematopoietic cells as well as in leukaemic progression.
Luisa, de Andrés-Aguayo +2 more
openaire +2 more sources
Recent work has shown that the Musashi 2 (Msi2) gene plays important roles in normal and malignant hematopoiesis. Here, we give an overview on the role of Msi2 in the regulation and function of primitive hematopoietic cells as well as in leukaemic progression.
Luisa, de Andrés-Aguayo +2 more
openaire +2 more sources
Identification of a putative intestinal stem cell and early lineage marker; musashi-1
Differentiation, 2003 There are few reliable markers for adult stem cells and none for those of the intestinal epithelium. Previously, indirect experimental approaches have predicted stem cell position and numbers.
Christopher S Potten +2 more
exaly +2 more sources