Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation [PDF]
Stem Cell Research & Therapy, 2022 Background Endometrial carcinoma is the most common gynecological cancer in Europe. Musashi-1 is known to be a key regulator of endometrial cancer stem cells and a negative prognostic marker.
Isabel Falke +8 more
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Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1 [PDF]
Nature Communications, 2023 Human RNA binding protein Musashi-1 binds various host transcripts as well as Zika virus RNA in neural progenitor cells. Here, Chen et al. characterise the interactions between Musashi-1 and its binding site using a combination of molecular and ...
Xiang Chen +11 more
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Musashi–1—A Stemness RBP for Cancer Therapy? [PDF]
Biology, 2021 The RNA–binding protein Musashi–1 (MSI1) promotes stemness during development and cancer. By controlling target mRNA turnover and translation, MSI1 is implicated in the regulation of cancer hallmarks such as cell cycle or Notch signaling.
Nadine Bley +6 more
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Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein [PDF]
Scientific Reports, 2022 The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation and is involved in cell proliferation and tumorigenesis.
Nitchakan Darai +5 more
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Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1 [PDF]
Cancer Cell International, 2020 Background Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expression to ascertain relevant ...
Aliaksandr A. Yarmishyn +10 more
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The Effects of Fecal Microbiota Transplantation on the Symptoms and the Duodenal Neurogenin 3, Musashi 1, and Enteroendocrine Cells in Patients With Diarrhea-Predominant Irritable Bowel Syndrome [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 IntroductionInteractions between the gut microbiota and enteroendocrine cells play important role in irritable bowel syndrome (IBS). Reduced stem cell densities and their differentiation into enteroendocrine cells may cause abnormal densities of the ...
Tarek Mazzawi +11 more
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Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria [PDF]
eLifeThe RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles.
Roswitha Dolcemascolo +13 more
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Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells [PDF]
Scientific Reports, 2017 Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation.
Guang-Yuh Chiou +9 more
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Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation [PDF]
Neoplasia: An International Journal for Oncology Research, 2019 Glioblastoma multiforme (GBM) is a lethal brain tumor with a mean survival time of 1 year. One major reason for therapeutic failure is that GBM cells have an extraordinary capacity to invade normal brain tissue beyond the surgical margin, accounting for ...
Jang-Chun Lin +4 more
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Musashi and Plasticity of Xenopus and Axolotl Spinal Cord Ependymal Cells [PDF]
Frontiers in Cellular Neuroscience, 2018 The differentiated state of spinal cord ependymal cells in regeneration-competent amphibians varies between a constitutively active state in what is essentially a developing organism, the tadpole of the frog Xenopus laevis, and a quiescent, activatable ...
Ellen A. G. Chernoff +4 more
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