Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA [PDF]
Molecules, 2017 Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation.
Ryo Iwaoka +6 more
doaj +5 more sources
Natural product (−)‐gossypol inhibits colon cancer cell growth by targeting RNA‐binding protein Musashi‐1 [PDF]
Molecular Oncology, 2015 Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. Additional MSI1 targets include the
Lan Lan, Hao Liu, Xiaoqing Wu
exaly +5 more sources
Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt [PDF]
Neuroscience Letters, 2009 journal ...
CHIBA Chikafumi, Kaneko Jun
core +4 more sources
Expression of Musashi-1 Increases in Bone Healing. [PDF]
Int J Mol Sci, 2021 Musashi-1 (MSI1) is an RNA-binding protein that regulates progenitor cells in adult and developing organisms to maintain self-renewal capacities. The role of musashi-1 in the bone healing environment and its relation with other osteogenic factors is unknown. In the current study, we analyze the expression of MSI1 in an experimental model of rat femoral
Padial-Molina M +7 more
europepmc +6 more sources
The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina. [PDF]
PLoS Genetics, 2016 Alternative pre-mRNA splicing expands the coding capacity of eukaryotic genomes, potentially enabling a limited number of genes to govern the development of complex anatomical structures.
Daniel Murphy +4 more
doaj +2 more sources
Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells
Cell Reports, 2023 Summary: The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic development remains poorly understood.
Youwei Chen +7 more
doaj +3 more sources
Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis [PDF]
International Journal of Molecular Sciences, 2022 Theresa Strauß +2 more
exaly +2 more sources
Correction: The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina. [PDF]
PLoS Genetics, 2016 [This corrects the article DOI: 10.1371/journal.pgen.1006256.].
PLOS Genetics Staff
doaj +2 more sources
Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung. [PDF]
Cancers (Basel), 2023 Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) have recently been grouped as lung neuroendocrine carcinomas (NECs). Because these lung NECs are clinically malignant and their treatment strategies differ from those of non-SCLC, the quality of diagnosis has a significant prognostic impact.
Izaki Y +6 more
europepmc +3 more sources
Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression. [PDF]
Cancers (Basel), 2021 Glioblastoma (GBM) is the most malignant brain tumor which is characterized by high proliferation and migration capacity. The poor survival rate has been attributed to limitations of the current standard therapies. The search for novel biological targets that can effectively hamper tumor progression remains extremely challenging.
Yang YP +12 more
europepmc +4 more sources