Results 21 to 30 of about 5,957 (192)

Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. [PDF]

Theranostics, 2020
Carcinomatous progression and recurrence are the main therapeutic challenges frequently faced by patients with refractory tumors. However, the underlined molecular mechanism remains obscure. Methods: We found Musashi-1 (MSI1) transported into cytosol under stress condition by confocal microscopy and cell fractionation.
Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH.   +17 more
europepmc   +3 more sources

The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation. [PDF]

J Biol Chem
Thyroid hormone (TH) is a critical regulator of cellular function and cell fate. The circulating TH level is relatively stable, while tissue TH action fluctuates according to cell type-specific mechanisms. Here, we focused on identifying mechanisms that regulate TH action through the type 2 deiodinase (D2) in glial cells.
Mohácsik P, Halmos E, Dorogházi B, Ruska Y, Wittmann G, Bianco AC, Fekete C, Gereben B.   +7 more
europepmc   +3 more sources

Inhibition of Musashi-1 enhances chemotherapeutic sensitivity in gastric cancer patient-derived xenografts. [PDF]

Exp Biol Med (Maywood), 2022
Musashi-1 (MSI1), a neural RNA-binding protein, is considered a gastric and intestinal stem cell marker. Although the function of MSI1 in gastric cancer has attracted increasing interest, it is not known whether MSI1 can be used as a biomarker to monitor gastric cancer development and response to treatment.
Liu F, Yang H, Zhang X, Sun X, Zhou J, Li Y, Liu Y, Zhuang Z, Wang G.   +8 more
europepmc   +3 more sources

Identification of a novel splice variant of the human musashi-1 gene. [PDF]

Oncol Lett, 2018
Musashi-1 (Msi1) is an evolutionarily conserved RNA-binding protein that has been reported to be the key regulator in malignancies and with involvement in cancer stemness. In the present study, a novel Msi1 transcript variant generated by alternative splicing was identified and termed Msi1 variant 2.
Ma L, Shan Y, Ma H, Elshoura I, Nafees M, Yang K, Yin W.   +6 more
europepmc   +4 more sources

Phosphorylation of MSI-1 is implicated in the regulation of associative memory in Caenorhabditis elegans.

PLoS Genetics, 2022
The Musashi family of RNA-binding proteins controls several biological processes including stem cell maintenance, cell division and neural function. Previously, we demonstrated that the C.
Pavlina Mastrandreas, Csaba Boglari, Andreas Arnold, Fabian Peter, Dominique J-F de Quervain, Andreas Papassotiropoulos, Attila Stetak   +6 more
doaj   +2 more sources

The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance

Biomarker Research, 2023
RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate.
Mark Sicking, Isabel Falke, Maria T. Löblein, Hans Th. Eich, Martin Götte, Burkhard Greve, Fabian M. Troschel   +6 more
doaj   +1 more source

Abdominal pain and mass caused by subserosal eosinophilic enteritis

Journal of Pediatric Surgery Case Reports, 2021
Eosinophilic gastroenteritis (EGE) causes acute abdomen, which is not diagnosed preoperatively and sometimes requires emergency surgery. Here we report a case of EGE, in which laparoscopy was performed to reveal the cause of recurrent abdominal pain, and
Masaki Miyao, Tsubasa Takahashi, Hiroshi Yoshida   +2 more
doaj   +1 more source

Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. [PDF]

Biomed Res Int, 2015
Background. Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis. Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells.
O'Valle F, Peregrina M, Crespo-Lora V, Galindo-Moreno P, Roman M, Padial-Molina M, Mesa F, Aneiros-Fernandez J, Aguilar D, Gonzalez-Rey E, Delgado M, Hernandez-Cortes P.   +11 more
europepmc   +7 more sources

Increased Expression of Musashi-1 Evidences Mesenchymal Repair in Maxillary Sinus Floor Elevation. [PDF]

Sci Rep, 2018
AbstractThis study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-
O'Valle F, de Buitrago JG, Hernández-Cortés P, Padial-Molina M, Crespo-Lora V, Cobo M, Aguilar D, Galindo-Moreno P.   +7 more
europepmc   +6 more sources

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. [PDF]

Science, 2017
Inherited microcephaly exposes Zika culprit Microcephaly has been the terrifying hallmark of the recent outbreak of Zika virus (ZIKV) in the Americas. How the virus damages brain development in the fetus is enigmatic. Chavali et al.
Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F.   +15 more
europepmc   +8 more sources