Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer [PDF]
Frontiers in Pharmacology, 2022 Musashi-2 (MSI2) is an evolutionally conserved RNA-binding protein and recently considered as an attractive therapeutic target in a wide spectrum of malignancies.
Xue Zhang +7 more
doaj +5 more sources
MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia [PDF]
Journal of Translational Medicine, 2023 Background The previous studies have revealed that abnormal RNA-binding protein Musashi-2 (MSI2) expression is associated with cancer progression through post-transcriptional mechanisms, however mechanistic details of this regulation in acute myeloid ...
Fanfan Li +11 more
doaj +4 more sources
Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT [PDF]
OncoTargets and Therapy, 2021 Local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. It is generally believed that this malignant behavior is stimulated by epithelial-mesenchymal transition (EMT)
Weiwei Sheng, Ming Dong
exaly +6 more sources
Prognostic value of Musashi 2 (MSI2) in cancer patients: A systematic review and meta-analysis [PDF]
Frontiers in Oncology, 2022 Musashi 2 (MSI2) is an RNA-binding protein that regulates mRNA translation of numerous intracellular targets and plays an important role in the development of cancer. However, the prognostic value of MSI2 in various cancers remains controversial. Herein,
Lin Jiang +5 more
doaj +4 more sources
Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells [PDF]
Nature, 2016 Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many life-saving regenerative therapies. However, despite their advantages for transplantation, their clinical use is restricted because HSCs in cord blood are found only in small numbers. Small molecules that enhance haematopoietic stem and progenitor cell (HSPC) expansion
Stefan Rentas +2 more
exaly +5 more sources
Jolkinolide B inhibits the progression of hepatocellular carcinoma by regulating Musashi-2 protein [PDF]
PLoS ONEHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths. However, the HCC treatment is still challenging. Herein, we aimed to reveal the anti-tumor effect of Jolkinolide B in HCC cell lines Huh-7 and SK-Hep-1. The results showed that Jolkinolide B inhibited the migration, invasion, and epithelial-to-mesenchymal transition ...
Tianchun Wu +6 more
doaj +4 more sources
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells [PDF]
Nature Communications, 2020 The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of the
Diu T. T. Nguyen +15 more
doaj +6 more sources
Crystal and solution structures of human oncoprotein Musashi‐2 N‐terminal RNA recognition motif 1 [PDF]
Proteins: Structure, Function and Bioinformatics, 2020 AbstractMusashi‐2 (MSI2) belongs to Musashi family of RNA binding proteins (RBP). Like Musashi‐1 (MSI1), it is overexpressed in a variety of cancers and is a promising therapeutic target. Both MSI proteins contain two N‐terminal RNA recognition motifs and play roles in posttranscriptional regulation of target mRNAs.
Lan Lan, Liang Xu, Liang Xu
exaly +6 more sources
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma. [PDF]
Leukemia, 2023 AbstractSOX11 overexpression has been associated with aggressive behavior of mantle cell lymphomas (MCL). SOX11 is overexpressed in embryonic and cancer stem cells (CSC) of some tumors. Although CSC have been isolated from primary MCL, their relationship to SOX11 expression and contribution to MCL pathogenesis and clinical evolution remain unknown ...
Sureda-Gómez M +15 more
europepmc +3 more sources
Increased expression of the RNA-binding protein Musashi-2 is associated with immune infiltration and predicts better outcomes in ccRCC patients [PDF]
Frontiers in Oncology, 2022 RNA-binding proteins (RBPs) mainly contribute to abnormalities in posttranscriptional gene regulation. The RBP Musashi-2, an evolutionarily conserved protein, has been characterized as an oncoprotein in various tumors.
Hui Li +12 more
doaj +2 more sources