Results 21 to 30 of about 4,861 (176)

Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition [PDF]

Cell & Bioscience, 2023
Background Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metastatic disease. The interaction between tumor cells and cancer-associated fibroblasts (CAFs) in tumor microenvironment is ...
Parinya Samart, Gayathri Heenatigala Palliyage, Surapol Issaragrisil, Sudjit Luanpitpong, Yon Rojanasakul   +4 more
doaj   +2 more sources

Update on the Progress of Musashi-2 in Malignant Tumors

Frontiers in Bioscience-Landmark
Since the discovery of the Musashi (MSI) protein, its ability to affect the mitosis of Drosophila progenitor cells has garnered significant interest among scientists. In the following 20 years, it has lived up to expectations.
Yiting Niu, Tao Zhou, Yanjun Li
doaj   +3 more sources

Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma [PDF]

Frontiers in Cell and Developmental Biology
IntroductionTreatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy.
Timo Habig, Lasse Reichstein, Kathrin A. Brücksken, Mark Sicking, Jan Labisch, Michael Oertel, Eberhard Korsching, Georg Lenz, Stephan Hailfinger, Burkhard Greve, Fabian M. Troschel, Hans Theodor Eich   +11 more
doaj   +2 more sources

Targeting Musashi-2 to counteract senescence and resistance in chronic myeloid leukemia: enhancing the efficacy of imatinib therapy [PDF]

BMC Cancer
Background Chronic myeloid leukemia (CML) is a myeloproliferative malignancy marked through the excessive proliferative growth of functional myeloid cells.
Khadija Arif, Maryam Yousaf, Dilawar Khan   +2 more
doaj   +2 more sources

MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer. [PDF]

Cancer Sci, 2019
AbstractIt has been well established that microRNA (miR)‐143 is downregulated in human bladder cancer (BC). Recent precision medicine has shown that mutations in BC are frequently observed in FGFR3, RAS and PIK3CA genes, all of which correlate with RAS signaling networks.
Tsujino T, Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y.   +14 more
europepmc   +4 more sources

Musashi-2 is a prognostic marker for the survival of patients with cervical cancer. [PDF]

Oncol Lett, 2018
Cervical cancer is one of the most common gynecological malignancies. Mousasi 2 (Msi2) is a RNA-binding protein that regulates various key cellular functions and has emerged as a crucial regulator of cancer development. However, the clinical significance and biological functions of Msi2 in cervical cancer remain unknown.
Liu Y, Fan Y, Wang X, Huang Z, Shi K, Zhou B.   +5 more
europepmc   +4 more sources

Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration [PDF]

Cell Communication and Signaling
Post-translational modifications (PTMs) of the non-histone protein high-mobility group protein B1 (HMGB1) are involved in modulating inflammation and immune responses.
Xiaole Meng, Risi Na, Xiao Peng, Hui Li, Wanxin Ouyang, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Huamei Tang, Guohong Zhuang, Zhihai Peng   +14 more
doaj   +2 more sources

PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells [PDF]

Stem Cell Reports, 2018
Summary: MSI2, which is expressed predominantly in hematopoietic stem and progenitor cells (HSPCs), enforces HSPC expansion when overexpressed and is upregulated in myeloid leukemias, indicating its regulated transcription is critical to balanced self ...
Muluken S. Belew, Sonam Bhatia, Ava Keyvani Chahi, Stefan Rentas, Jonathan S. Draper, Kristin J. Hope   +5 more
doaj   +2 more sources

CircMALAT1 promotes cancer stem‐like properties and chemoresistance via regulating Musashi‐2/c‐Myc axis in esophageal squamous cell carcinoma [PDF]

MedComm
The primary challenge in treating esophageal squamous cell carcinoma (ESCC) is resistance to chemotherapy. Cancer stem cell (CSC) is the root cause of tumor drug resistance. Therefore, targeting CSCs has been considered promising therapeutic strategy for
Zitong Zhao, Yingni Deng, Jing Han, Liying Ma, Yumeng Zhu, Hua Zhang, Zhixu He, Yongmei Song   +7 more
doaj   +2 more sources

Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin. [PDF]

PLoS ONE, 2015
RNA-binding protein Musashi-2 (Msi2) is known to play a critical role in leukemogenesis and contributes to poor clinical prognosis in acute myeloid leukemia (AML). However, the effect of Msi2 silencing on treatment for AML still remains poorly understood.
Yixiang Han, Aifang Ye, Yan Zhang, Zhimin Cai, Wei Wang, Lan Sun, Songfu Jiang, Jianbo Wu, Kang Yu, Shenghui Zhang   +9 more
doaj   +4 more sources