Increased musashi 2 expression indicates a poor prognosis and promotes malignant phenotypes in gastric cancer. [PDF]
Oncol Lett, 2019 Musashi 2 (MSI2), a marker of stem and progenitor cells, has been identified as an oncogene. Various investigations have revealed that MSI2 is differently expressed in several types of blood cancer and solid cancers. However, its expression and biological functions in gastric cancer (GC) remain unclear.
Yang Z, Li J, Shi Y, Li L, Guo X.
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TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma [PDF]
Nature Communications, 2022 To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and driver of
Tatiana Erazo +22 more
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Update on the Progress of Musashi-2 in Malignant Tumors
Frontiers in Bioscience-LandmarkSince the discovery of the Musashi (MSI) protein, its ability to affect the mitosis of Drosophila progenitor cells has garnered significant interest among scientists. In the following 20 years, it has lived up to expectations.
Yiting Niu, Tao Zhou, Yanjun Li
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Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket. [PDF]
Oncotarget, 2017 RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal RRMs (RNA-recognition Motifs, also
Lan L +5 more
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Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition [PDF]
Cell & Bioscience, 2023 Background Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metastatic disease. The interaction between tumor cells and cancer-associated fibroblasts (CAFs) in tumor microenvironment is ...
Parinya Samart +4 more
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HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells [PDF]
Nature Communications, 2020 The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of the
Diu T. T. Nguyen +15 more
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Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma [PDF]
Frontiers in Cell and Developmental BiologyIntroductionTreatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy.
Timo Habig +11 more
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RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family [PDF]
Asian Journal of Andrology, 2015 Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy ...
Jessie M Sutherland +3 more
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Targeting Musashi-2 to counteract senescence and resistance in chronic myeloid leukemia: enhancing the efficacy of imatinib therapy [PDF]
BMC CancerBackground Chronic myeloid leukemia (CML) is a myeloproliferative malignancy marked through the excessive proliferative growth of functional myeloid cells.
Khadija Arif +2 more
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Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA [PDF]
Molecules, 2017 Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation.
Ryo Iwaoka +6 more
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