Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). [PDF]
Oncogenesis, 2021 Makhov P +22 more
europepmc +3 more sources
Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration [PDF]
Cell Communication and SignalingPost-translational modifications (PTMs) of the non-histone protein high-mobility group protein B1 (HMGB1) are involved in modulating inflammation and immune responses.
Xiaole Meng +14 more
doaj +2 more sources
Mnemonic of Principles for Effective Specialist-Generalist Conferences: The BRIDGE. [PDF]
J Gen Fam MedJournal of General and Family Medicine, Volume 27, Issue 2, March 2026.
Kanzawa Y +8 more
europepmc +2 more sources
Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target. [PDF]
Leukemia, 2021 Palacios F +15 more
europepmc +3 more sources
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia [PDF]
Nature Medicine, 2010 RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo ...
Michael G. Kharas +19 more
+10 more sources
Crystal and solution structures of human oncoprotein Musashi‐2 N‐terminal RNA recognition motif 1 [PDF]
Proteins: Structure, Function and Bioinformatics, 2020 Lan Lan, Minli Xing, Scott Lovell
exaly +2 more sources
Musashi-2 is a prognostic marker for the survival of patients with cervical cancer. [PDF]
Oncol Lett, 2018 Cervical cancer is one of the most common gynecological malignancies. Mousasi 2 (Msi2) is a RNA-binding protein that regulates various key cellular functions and has emerged as a crucial regulator of cancer development. However, the clinical significance and biological functions of Msi2 in cervical cancer remain unknown.
Liu Y +5 more
europepmc +4 more sources
MUSASHI-2 duels in myelodysplastic syndromes. [PDF]
Cell Cycle, 2016 Ho TC, Taggart J, Kharas MG.
europepmc +4 more sources
Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma. [PDF]
Int J Mol Sci, 2019 Troiano G +12 more
europepmc +3 more sources
Abstract 3669: Defining an ELAVL1-Musashi 2 signaling cascade in neuroblastoma tumorigenesis
Cancer Research, 2019 Abstract Background: Patients with high-risk neuroblastoma endure an extremely intense, multidrug treatment regimen and yet, approximately half of them die, thus mandating a better approach to this cancer. Our laboratory is investigating the overarching hypothesis that RNA binding proteins (RBPs), which play key roles in balancing ...
Selma M. Cuya +4 more
openalex +2 more sources