RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family
Asian Journal of Andrology, 2015 Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy ...
Jessie M Sutherland +3 more
doaj +1 more source
Differences in stem cell marker and osteopontin expression in primary and recurrent glioblastoma
Cancer Cell International, 2022 Background Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may be in part due to so called glioma stem cells. However, there is no established marker to identify these stem cells.
Bülent Polat +10 more
doaj +1 more source
Zebrafish Stem/Progenitor Factor msi2b Exhibits Two Phases of Activity Mediated by Different Splice Variants [PDF]
, 2014 The Musashi (Msi) family of RNA-binding proteins is important in stem and differentiating cells in many species. Here, we present a zebrafish gene/protein trap line gt(msi2b-citrine)(ct) (57) (a) that expresses a Citrine fusion protein with endogenous ...
Bronner, Marianne E. +3 more
core +1 more source
Characterization of a Novel Rat Hepatitis E Virus Isolated from an Asian Musk Shrew (Suncus murinus)
Viruses, 2020 The Asian musk shrew (shrew) is a new reservoir of a rat hepatitis E virus (HEV) that has been classified into genotype HEV-C1 in the species Orthohepevirus C.
Huimin Bai +9 more
doaj +1 more source
Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones. [PDF]
PLoS ONE, 2014 Cancer stem cells (CSC) were isolated via a non-adherent neurosphere assay from three glioma cell lines: LI, U87, and U373. Using a clonal assay, two clones (D2 and F11) were selected from spheres derived from LI cells and were characterized for the ...
Fortunata Iacopino +7 more
doaj +1 more source
Regulation of stress-induced hematopoiesis [PDF]
, 2015 Purpose of review: Hematopoietic stem cells can self-renew and also give rise to the entire repertoire of hematopoietic cells. During acute infectious and inflammatory stresses, the hematopoietic system can quickly adapt to demand by increasing output of
Baltimore, David, Zhao, Jimmy L.
core +1 more source
Aggressive myeloid leukemia formation is directed by the Musashi 2/Numb pathway [PDF]
Cancer Biology & Therapy, 2010 Chronic myeloid leukemia (CML) progresses from a chronic phase to a deadly blast crisis phase. While it is known that BCR-ABL initiates the disease and that secondary molecular and genetic abnormalities likely contribute to progression of the disease to blast crisis, details regarding the mechanism(s) of blast phase progression are lacking.
Lori N, Griner, Gary W, Reuther
openaire +2 more sources
Tissue-specific control of brain-enriched miR-7 biogenesis [PDF]
, 2013 MicroRNA (miRNA) biogenesis is a highly regulated process in eukaryotic cells. Several mature miRNAs exhibit a tissue-specific pattern of expression without an apparent tissue-specific pattern for their corresponding primary transcripts. This discrepancy
Choudhury, Nila Roy +6 more
core +1 more source
Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry [PDF]
, 2023 RNA-binding proteins (RBPs) are key post-transcriptional regulators of gene expression, and thus underlie many important biological processes. Here, we developed a strategy that entails extracting a “hotspot pharmacophore” from the structure of a protein-
Adeshina, Yusuf +16 more
core +1 more source
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation [PDF]
, 2017 The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β-p38MAPK balances HSPC self-renewal and differentiation.
Aronow, Bruce J. +9 more
core +1 more source