Biomarker Research, 2023 RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate.
Mark Sicking +6 more
doaj +1 more source
Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour. [PDF]
PLoS ONE, 2012 The vertebrate RNA-binding proteins, Musashi-1 (Msi-1) and Musashi-2 (Msi-2) are expressed in multiple stem cell populations. A role for Musashi proteins in preventing stem cell differentiation has been suggested from genetic analysis of the Drosophila ...
Nicole A Siddall +7 more
doaj +1 more source
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia [PDF]
Nature Medicine, 2010 RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo ...
Kharas, Michael G. +19 more
openaire +4 more sources
Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein
Scientific Reports, 2022 The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation and is involved in cell proliferation and tumorigenesis.
Nitchakan Darai +5 more
doaj +1 more source
Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia [PDF]
, 2022 Classical aniridia is a congenital and progressive panocular disorder almost exclusively caused by heterozygous loss-of-function variants at the PAX6 locus. We report nine individuals from five families with severe aniridia and/or microphthalmia (with no
Ansari M. +20 more
core +7 more sources
Communications Biology, 2022 The RNA-binding proteins, Musashi 1 and 2, regulate splicing of photoreceptor-specific alternative exons and activate protein expression, and are essential for promoting translation of proteins required for vision and photoreceptor survival.
Fatimah Matalkah +5 more
doaj +1 more source
Lack of Musashi‐2 induces type
The FASEB Journal, 2023 Abstract Skeletal muscle is a highly plastic tissue, adapting its structure and metabolism in response to diverse conditions such as contractile activity, nutrients, and diseases. Finding a novel master regulator of muscle mass and quality will provide new therapeutic targets for the prevention and treatment of muscle weakness ...
Yasuro Furuichi +4 more
openaire +2 more sources
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket. [PDF]
Oncotarget, 2017 RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal RRMs (RNA-recognition Motifs, also
Lan L +5 more
europepmc +3 more sources
Musashi: Takezo the Ronin, Aggression, and Erich Fromm's Psychological Perspective
Izumi, 2021 This study explores the character of Takezo the ronin in Musashi by Eiji Yoshikawa through the psychological perspective of aggression. This research specifically aims to (a) explore Takezo's psychology of aggression as a ronin and (b) the impact of ...
Anas Ahmadi
doaj +1 more source
mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients [PDF]
, 2011 Background Metastatic non-small-cell lung cancer (NSCLC) has a dismal prognosis. EGFR is overexpressed or mutated in a large proportion of cases.
Mariacarmela Santarpia +14 more
core +1 more source