Results 61 to 70 of about 17,657,887 (204)
Lack of Musashi‐2 induces type
The FASEB Journal, 2023 Abstract Skeletal muscle is a highly plastic tissue, adapting its structure and metabolism in response to diverse conditions such as contractile activity, nutrients, and diseases. Finding a novel master regulator of muscle mass and quality will provide new therapeutic targets for the prevention and treatment of muscle weakness ...
Yasuro Furuichi +4 more
openaire +2 more sources
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
Nature Communications, 2019 The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
Gerard Minuesa +31 more
doaj +1 more source
, 2022 RNA-binding proteins (RBPs) mainly contribute to abnormalities in posttranscriptional gene regulation. The RBP Musashi-2, an evolutionarily conserved protein, has been characterized as an oncoprotein in various tumors.
Xiaole Meng (13991655) +7 more
core +1 more source
, 2016 SD is funded through a MASTS PhD studentship (St Andrews, UK). IMLS gratefully acknowledges previous funding from Marie Curie IEF postdoctoral fellowship, FP7 People Programme (Barcelona, Spain); as well as MASTS (Marine Alliance for Science and ...
Jordi Garcia-Fernàndez +13 more
core +1 more source
DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer. [PDF]
Oncogene, 2017 The gene encoding 'deleted in breast cancer 2' (DBC2), also referred to as RHOBTB2 (Rho-related BTB domain-containing protein 2), is classified as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; however, it is unclear if the substrate adaptor function of DBC2 is ...
Choi YM +6 more
europepmc +4 more sources
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs [PDF]
Journal of Experimental Medicine, 2014 Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisions.
Park, Sun-Mi +11 more
openaire +4 more sources
Frontiers in Neurorobotics, 2022 Dynamic manipulation of flexible objects such as fabric, which is difficult to modelize, is one of the major challenges in robotics. With the development of deep learning, we are beginning to see results in simulations and some actual robots, but there ...
Kento Kawaharazuka +4 more
doaj +1 more source
Engineering Strain‐Stiffening Granular Hydrogels for 3D‐Printed Tissue‐Mimicry
Advanced Materials, EarlyView.A 3D‐printable strain‐stiffening double‐network granular hydrogel (SDGH) enables independent, region‐specific tuning of toe (EToe) and heel (EHeel) moduli through control of microgel packing and network composition. This platform replicates tissue‐like nonlinear mechanics and allows fabrication of high‐fidelity, multilayered aortic valves with ...
Hyeokju Chae +9 more
wiley +1 more source
Prognostic significance of the Musashi-2 (MSI2) gene in childhood acute lymphoblastic leukemia
Neoplasma, 2016 The prognostic value of the Musashi-2 (MSI2) gene has not yet been studied in childhood acute lymphoblastic leukemia (ALL). In our study, MSI2 mRNA levels of 119 childhood patients with newly-diagnosed ALL were examined and analyzed with regard to clinical characteristics and outcomes.
H Z, Zhao +7 more
openaire +3 more sources
Capacity of Human Dental Follicle Cells to Differentiate into Neural Cells In Vitro
Stem Cells International, 2017 The dental follicle is an ectomesenchymal tissue surrounding the developing tooth germ. Human dental follicle cells (hDFCs) have the capacity to commit to differentiation into multiple cell types.
Shingo Kanao +6 more
doaj +1 more source