Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs [PDF]
Journal of Experimental Medicine, 2014 Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisions.
Steve Lianoglou +2 more
exaly +7 more sources
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. [PDF]
PLoS ONE, 2021 BackgroundThe RNA-binding protein Musashi-2 (MSI2) controls the translation of proteins that support stem cell identity and lineage determination and is associated with progression in some cancers.
Leonid Kharin +9 more
doaj +5 more sources
MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma. [PDF]
Cancer Sci, 2021 AbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are effective in patients with non–small‐cell lung cancer (NSCLC) harboring EGFR mutations. However, due to acquired resistance to EGFR‐TKIs, even patients on third‐generation osimertinib have a poor prognosis. Resistance mechanisms are still not fully understood.
Yiming R +9 more
europepmc +7 more sources
Regulation of VEGFR2 and AKT Signaling by Musashi-2 in Lung Cancer. [PDF]
Cancers (Basel), 2023 Lung cancer is the most frequently diagnosed cancer type and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents most of the diagnoses of lung cancer. Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both ...
Bychkov I +5 more
europepmc +4 more sources
OR26-5 Musashi-2 Regulatory Interactions Promote Adrenal Steroidogenesis [PDF]
J Endocr Soc, 2022 Abstract The adrenal gland is the site of steroid hormone synthesis. These hormones regulate many physiological processes including metabolism, blood pressure and volume, and sexual characteristic development. While signaling pathways, steroidogenic enzymes, and transcription factors have all been well characterized, little is known ...
Baldwin, Amber +4 more
europepmc +2 more sources
RNA-Binding Protein Musashi-2 Inhibits Aldosterone Production [PDF]
J Endocr Soc, 2021 Abstract The adrenal cortex is the site of steroid hormone synthesis. These hormones control important physiological processes like metabolism, blood pressure and volume, and sexual characteristic development. While the signaling pathways, transcription factors, and steroidogenic enzymes are well-characterized, surprisingly little is ...
Bartholomay K, Baldwin A, Mukherjee N.
europepmc +3 more sources
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation [PDF]
Biological Procedures Online, 2023 Background Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit their malignant biological ...
Xiaole Meng +14 more
doaj +2 more sources
Musashi and Plasticity of Xenopus and Axolotl Spinal Cord Ependymal Cells [PDF]
Frontiers in Cellular Neuroscience, 2018 The differentiated state of spinal cord ependymal cells in regeneration-competent amphibians varies between a constitutively active state in what is essentially a developing organism, the tadpole of the frog Xenopus laevis, and a quiescent, activatable ...
Ellen A. G. Chernoff +4 more
doaj +4 more sources
TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma [PDF]
Nature Communications, 2022 To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and driver of
Tatiana Erazo +22 more
doaj +2 more sources
Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression [PDF]
Molecular Therapy: Nucleic Acids, 2021 Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and ...
Maria Sabater-Arcis +5 more
doaj +2 more sources