Results 11 to 20 of about 17,657,887 (204)

Prognostic value of Musashi 2 (MSI2) in cancer patients: A systematic review and meta-analysis [PDF]

Frontiers in Oncology, 2022
Musashi 2 (MSI2) is an RNA-binding protein that regulates mRNA translation of numerous intracellular targets and plays an important role in the development of cancer. However, the prognostic value of MSI2 in various cancers remains controversial. Herein,
Lin Jiang, Shanshan Xue, Jie Xu, Xiaoyang Fu, Jing Wei, Chuanmeng Zhang   +5 more
doaj   +4 more sources

Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma. [PDF]

Leukemia, 2023
AbstractSOX11 overexpression has been associated with aggressive behavior of mantle cell lymphomas (MCL). SOX11 is overexpressed in embryonic and cancer stem cells (CSC) of some tumors. Although CSC have been isolated from primary MCL, their relationship to SOX11 expression and contribution to MCL pathogenesis and clinical evolution remain unknown ...
Sureda-Gómez M, Balsas P, Rodríguez ML, Nadeu F, De Bolòs A, Eguileor Á, Kulis M, Castellano G, López C, Giné E, Demajo S, Jares P, Martín-Subero JI, Beà S, Campo E, Amador V.   +15 more
europepmc   +5 more sources

Regulation of VEGFR2 and AKT Signaling by Musashi-2 in Lung Cancer. [PDF]

Cancers (Basel), 2023
Lung cancer is the most frequently diagnosed cancer type and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents most of the diagnoses of lung cancer. Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both ...
Bychkov I, Topchu I, Makhov P, Kudinov A, Patel JD, Boumber Y.   +5 more
europepmc   +6 more sources

Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT [PDF]

OncoTargets and Therapy, 2021
Local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. It is generally believed that this malignant behavior is stimulated by epithelial-mesenchymal transition (EMT)
Weiwei Sheng, Yuteng Ma, Ming Dong
exaly   +6 more sources

Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin. [PDF]

PLoS ONE, 2015
RNA-binding protein Musashi-2 (Msi2) is known to play a critical role in leukemogenesis and contributes to poor clinical prognosis in acute myeloid leukemia (AML). However, the effect of Msi2 silencing on treatment for AML still remains poorly understood.
Yixiang Han, Aifang Ye, Yan Zhang, Zhimin Cai, Wei Wang, Lan Sun, Songfu Jiang, Jianbo Wu, Kang Yu, Shenghui Zhang   +9 more
doaj   +5 more sources

RNA-Binding Protein Musashi-2 Inhibits Aldosterone Production [PDF]

J Endocr Soc, 2021
Abstract The adrenal cortex is the site of steroid hormone synthesis. These hormones control important physiological processes like metabolism, blood pressure and volume, and sexual characteristic development. While the signaling pathways, transcription factors, and steroidogenic enzymes are well-characterized, surprisingly little is ...
Bartholomay K, Baldwin A, Mukherjee N.
europepmc   +4 more sources

MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer. [PDF]

Cancer Sci, 2019
AbstractIt has been well established that microRNA (miR)‐143 is downregulated in human bladder cancer (BC). Recent precision medicine has shown that mutations in BC are frequently observed in FGFR3, RAS and PIK3CA genes, all of which correlate with RAS signaling networks.
Tsujino T, Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y.   +14 more
europepmc   +5 more sources

The Pluripotency Factor Musashi-2 Is a Novel Target for Lung Cancer Therapy [PDF]

Ann Am Thorac Soc, 2018
Abstract Previously we reported that mithramycin represses multiple pathways critical for stem cell signaling and pluripotency in lung cancer cells. This phenomenon coincided with decreased side population fraction and dramatic dose-dependent growth arrest of lung cancer cells in vitro and in vivo.
Zhang M, Xi S, Shukla V, Hong J, Chen H, Xiong Y, Ripley R, Hoang C, Schrump D.   +8 more
europepmc   +4 more sources

Jolkinolide B inhibits the progression of hepatocellular carcinoma by regulating Musashi-2 protein [PDF]

PLoS ONE
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths. However, the HCC treatment is still challenging. Herein, we aimed to reveal the anti-tumor effect of Jolkinolide B in HCC cell lines Huh-7 and SK-Hep-1. The results showed that Jolkinolide B inhibited the migration, invasion, and epithelial-to-mesenchymal transition ...
Tianchun Wu, Han Yang, Jinjin Li, Hongbo Fang, Xiaoyi Shi, Jie Li, Liushun Feng   +6 more
doaj   +4 more sources

The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance

Biomarker Research, 2023
RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate.
Mark Sicking, Isabel Falke, Maria T. Löblein, Hans Th. Eich, Martin Götte, Burkhard Greve, Fabian M. Troschel   +6 more
doaj   +2 more sources