Ectopic Expression of Musashi-1 in Alzheimer Disease and Pick Disease [PDF]
Journal of Neuropathology and Experimental Neurology, 2005 Abnormal accumulation of proteins in filamentous cytoplasmic inclusions is a hallmark of several neurodegenerative disorders, including Alzheimer disease (AD) and Pick disease (PD). Musashi-1 (Msi-1), an RNA-binding protein associated with neural progenitor cells, has been shown by others to increase the accumulation of tau isoforms in intracellular ...
Mark A, Lovell, William R, Markesbery
openaire +2 more sources
Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly. [PDF]
Cell Host Microbe, 2017 Infection with Zika virus (ZIKV) during pregnancy may cause severe developmental defects in the human brain via unknown mechanisms. In a recent issue of Science, Chavali et al. (2017) identified a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of ZIKV replication and apoptosis observed in these cells during ...
Klein RS.
europepmc +4 more sources
Unique Molecular Features in High-Risk Histology Endometrial Cancers [PDF]
, 2019 Endometrial cancer is the most common gynecologic malignancy in the United States and the sixth most common cancer in women worldwide. Fortunately, most women who develop endometrial cancer have low-grade early-stage endometrioid carcinomas, and simple ...
Collins, Kaitlyn +4 more
core +1 more source
Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour. [PDF]
PLoS ONE, 2012 The vertebrate RNA-binding proteins, Musashi-1 (Msi-1) and Musashi-2 (Msi-2) are expressed in multiple stem cell populations. A role for Musashi proteins in preventing stem cell differentiation has been suggested from genetic analysis of the Drosophila ...
Nicole A Siddall +7 more
doaj +1 more source
Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. [PDF]
, 2016 Natural killer (NK) cells are functionally suppressed in the glioblastoma multiforme (GBM) tumor microenvironment. We have recently shown that survival and differentiation of cancer stem-like cells (CSCs)/poorly differentiated tumors are controlled ...
Bui, Vickie T +8 more
core +1 more source
Single-molecule transcript counting of stem-cell markers in the mouse intestine [PDF]
, 2011 available in PMC 2012 July 1.Determining the molecular identities of adult stem cells requires technologies for sensitive transcript detection in tissues.
Blat, Irene C. +8 more
core +1 more source
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease
Acta Neuropathologica Communications, 2018 Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with structural and functional alterations of brain cells causing progressive deterioration of memory and other cognitive functions. Recent studies demonstrate that several
Urmi Sengupta +5 more
doaj +1 more source
A Transcriptome for the Study of Early Processes of Retinal Regeneration in the Adult Newt, Cynops pyrrhogaster [PDF]
, 2014 Retinal regeneration in the adult newt is a useful system to uncover essential mechanisms underlying the regeneration of body parts of this animal as well as to find clues to treat retinal disorders such as proliferative vitreoretinopathy.
Casco-Robles Roman M. +9 more
core +1 more source
Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells [PDF]
, 2011 Background The specific genetic regulation of neural primordial cell determination is of great interest in stem cell biology. The Musashi1 (Msi1) protein, which belongs to an evolutionarily conserved family of RNA-binding proteins, is a marker for neural
Satoshi Kawase +9 more
core +1 more source
RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family
Asian Journal of Andrology, 2015 Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy ...
Jessie M Sutherland +3 more
doaj +1 more source