Results 51 to 60 of about 21,241,008 (156)

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

open access: yesNature Communications, 2020
Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used ...
Kyle Spinler   +18 more
doaj   +1 more source

Mechanism of RNA recognition by a Musashi RNA-binding protein

open access: yesCurrent Research in Structural Biology, 2022
The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an intestinal and neural stem cell marker, has been more recently found to be over ...
Jinan Wang   +4 more
doaj   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

open access: yesAdvanced Functional Materials, Volume 36, Issue 49, 18 June 2026.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim   +7 more
wiley   +1 more source

Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite

open access: yeseLife, 2014
Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function.
Carina C Clingman   +6 more
doaj   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam   +9 more
wiley   +1 more source

Musashi: Takezo the Ronin, Aggression, and Erich Fromm's Psychological Perspective

open access: yesIzumi, 2021
This study explores the character of Takezo the ronin in Musashi by Eiji Yoshikawa through the psychological perspective of aggression. This research specifically aims to (a) explore Takezo's psychology of aggression as a ronin and (b) the impact of ...
Anas Ahmadi
doaj   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Musashi-1 and miR-147 precursor interaction mediates synergistic tumorigenesis induced by co-infection of avian retroviruses in chicken

open access: yes, 2022
The original data of the western blot results in the musashi-1 and miR-147 precursor interaction mediates synergistic tumorigenesis induced by co-infection of avian retroviruses in chickenTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO
Zhou, D (via Mendeley Data)
core   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

open access: yesAdvanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Meniscus Pixel Printing for Contact‐Lens Vision Sensing and Robotic Control

open access: yesAdvanced Functional Materials, Volume 36, Issue 41, 21 May 2026.
A visual‐sensing contact lens is enabled by meniscus pixel printing (MPP), which rapidly patterns a 200 µm perovskite photodetector pixel in 1 s without masks, vacuum processing, or bulky equipment. A deep‐learning‐based super‐resolution reconstructs sparse on‐lens signals into 80 × 80 high‐resolution visual information, while AI‐driven eye‐tracking ...
Byung‐Hoon Gong   +7 more
wiley   +1 more source

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