Results 1 to 10 of about 2,567 (167)

Arabidopsis MSI1 functions in photoperiodic flowering time control [PDF]

Frontiers in Plant Science, 2014
Appropriate timing of flowering is crucial for crop yield and the reproductive success of plants. Flowering can be induced by a number of molecular pathways that respond to internal and external signals such as photoperiod, vernalization or light quality,
Yvonne Steinbach, Lars Hennig
exaly   +6 more sources

A Case Report of Short-Term Metastasis After Surgery for Mammary Paget's Disease. [PDF]

Clin Case Rep
ABSTRACT Mammary Paget's disease (MPD) with ductal carcinoma in situ (DCIS) pathology can metastasize rapidly. HER2‐positive status likely drives aggression, warranting early postoperative systemic imaging and close surveillance. Anti‐HER2 agents require proactive toxicity management.
Wang C, Yan B, Wang J, Zhou J, Li D, Gao X, Pan Y.   +6 more
europepmc   +2 more sources

Manipulating Zika virus RNA tertiary structure for developing tissue-specific attenuated vaccines [PDF]

EMBO Molecular Medicine
Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions.
Xiang Chen, Meng-Li Cheng, Xing-Yao Huang, Meng-Xu Sun, Rui-Ting Li, Mei Wu, Yu-Yan Li, Qian Xu, Meng-Yue Guan, Hui Zhao, Cheng-Feng Qin   +10 more
doaj   +2 more sources

The oncogene Musashi1 encodes novel miRNAs in breast cancer [PDF]

Scientific Reports, 2023
RNA-binding protein Musashi1 (MSI1) shows an increased expression level in several cancers and has been introduced as a prognostic marker in some malignancies.
Liana Lachinani, Mahboobeh Forouzanfar, Kianoush Dormiani, Bahram Mohammad Soltani, Kamran Dolatshahi, Sayyed Mohammadreza Hakimian, Sadat Dokanehiifard, Mohammad Hossein Nasr-Esfahani   +7 more
doaj   +2 more sources

Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation [PDF]

Journal of Virology
A successful strategy employed by RNA viruses to achieve replication is to evade host cell RNase degradation. However, the mechanisms through which plus-strand RNA viruses effectively shield viral RNA from cellular ribonuclease degradation remain unclear.
Defang Zhou, Menglu Xu, Qingjie Liu, Ruixue Xin, Gege Cui, Longying Ding, Xiaoyang Liu, Xinyue Zhang, Tianxing Yan, Jing Zhou, Shuhai He, Liangyu Yang, Bin Xiang, Ziqiang Cheng   +13 more
doaj   +2 more sources

Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma [PDF]

Frontiers in Cell and Developmental Biology
IntroductionTreatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy.
Timo Habig, Lasse Reichstein, Kathrin A. Brücksken, Mark Sicking, Jan Labisch, Michael Oertel, Eberhard Korsching, Georg Lenz, Stephan Hailfinger, Burkhard Greve, Fabian M. Troschel, Hans Theodor Eich   +11 more
doaj   +2 more sources

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach. [PDF]

Adv Sci (Weinh)
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
You C, Yang H, Zhao Y, Wang X, Wei S, Chen N, Zhang Y, Liu L, Qian W, Li S, Gao W.   +10 more
europepmc   +2 more sources

Musashi–1—A Stemness RBP for Cancer Therapy?

Biology, 2021
The RNA–binding protein Musashi–1 (MSI1) promotes stemness during development and cancer. By controlling target mRNA turnover and translation, MSI1 is implicated in the regulation of cancer hallmarks such as cell cycle or Notch signaling.
Nadine Bley, Ali Hmedat, Simon Müller, Robin Rolnik, Alexander Rausch, Marcell Lederer, Stefan Hüttelmaier   +6 more
doaj   +1 more source

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Cell Reports, 2023
Summary: The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic development remains poorly understood.
Youwei Chen, Ying Chen, Qianyan Li, Huahua Liu, Jiazhen Han, Hailin Zhang, Liming Cheng, Gufa Lin   +7 more
doaj   +1 more source

RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. [PDF]

PLoS ONE, 2012
Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the progression of glioma.
Jun Muto, Takao Imai, Daisuke Ogawa, Yoshinori Nishimoto, Yohei Okada, Yo Mabuchi, Takeshi Kawase, Akio Iwanami, Paul S Mischel, Hideyuki Saya, Kazunari Yoshida, Yumi Matsuzaki, Hideyuki Okano   +12 more
doaj   +1 more source