Results 21 to 30 of about 2,567 (167)

Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells

Stem Cell Research & Therapy, 2020
RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers.
Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani, Ali Osmay Gure, Kamran Ghaedi   +5 more
doaj   +1 more source

Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

Cell Reports, 2020
Summary: A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying intestinal regeneration remains unclear.
Xiaole Sheng, Ziguang Lin, Cong Lv, Chunlei Shao, Xueyun Bi, Min Deng, Jiuzhi Xu, Christian F. Guerrero-Juarez, Mengzhen Li, Xi Wu, Ran Zhao, Xu Yang, Guilin Li, Xiaowei Liu, Qingyu Wang, Qing Nie, Wei Cui, Shan Gao, Hongquan Zhang, Zhihua Liu, Yingzi Cong, Maksim V. Plikus, Christopher J. Lengner, Bogi Andersen, Fazheng Ren, Zhengquan Yu   +25 more
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Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival

Molecular Cancer, 2010
Background Musashi1 (Msi1) is a conserved RNA-binding protein that regulates the Notch and Wnt pathways, and serves as a stem cell marker in the breast and other tissues.
Wang Xiao-Yang, Penalva Luiz OF, Yuan Hongyan, Linnoila R Ilona, Lu Jiachun, Okano Hideyuki, Glazer Robert I   +6 more
doaj   +1 more source

Mechanism of RNA recognition by a Musashi RNA-binding protein

Current Research in Structural Biology, 2022
The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an intestinal and neural stem cell marker, has been more recently found to be over ...
Jinan Wang, Lan Lan, Xiaoqing Wu, Liang Xu, Yinglong Miao   +4 more
doaj   +1 more source

Arabidopsis MSI1 is required for epigenetic maintenance of reproductive development [PDF]

Development, 2003
WD40 repeat proteins similar to yeast MSI1 are conserved in animals and plants, in which they participate in complexes involved in chromatin metabolism. Although MSI1-like proteins are well characterised biochemically,their function in the development of multicellular eukaryotes is not well understood.
Lars, Hennig, Patti, Taranto, Marcel, Walser, Nicole, Schönrock, Wilhelm, Gruissem   +4 more
openaire   +2 more sources

Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy

BMC Cancer, 2008
Background Musashi1 (Msi1) is an RNA binding protein with a central role during nervous system development and stem cell maintenance. High levels of Msi1 have been reported in several malignancies including brain tumors thereby associating Msi1 and ...
Hung Jaclyn Y, Burns Suzanne C, Burton Tarea L, Sanchez-Diaz Patricia C, Penalva Luiz OF   +4 more
doaj   +1 more source

Increased expression of MUSASHI1 in epithelial breast cancer cells is due to down regulation of miR-125b

BMC Molecular and Cell Biology, 2021
Background Musashi1 (MSI1) is an oncogenic protein with a crucial role in the proliferation and characteristics of the epithelial cells in breast cancer. The change in expression of MSI1 has a role in solid tumor progression.
Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi   +4 more
doaj   +1 more source

Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells

Molecular Brain, 2011
Background The specific genetic regulation of neural primordial cell determination is of great interest in stem cell biology. The Musashi1 (Msi1) protein, which belongs to an evolutionarily conserved family of RNA-binding proteins, is a marker for neural
Kawase Satoshi, Imai Takao, Miyauchi-Hara Chikako, Yaguchi Kunio, Nishimoto Yoshinori, Fukami Shin-ichi, Matsuzaki Yumi, Miyawaki Atsushi, Itohara Shigeyoshi, Okano Hideyuki   +9 more
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Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3

Scientific Reports, 2017
The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency of stem cells.
Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Benoit Laurent, Chih-Hung Hsu, Chih-Ming Pan, Wan-Ru Jiang, Pau-Yuan Chen, Hsin-I Ma, Yi-Wei Chen, Pin-I Huang, Arthur Chiou, Shih-Hwa Chiou   +12 more
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miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties

Biomedicines, 2021
MicroRNAs (miRNAs) could be potential biomarkers for glioblastoma multiforme (GBM) prognosis and response to therapeutic agents. We previously demonstrated that the cancer stem cell marker Musashi-1 (MSI1) is an RNA binding protein that promotes ...
Jang-Chun Lin, Chun-Yuan Kuo, Jo-Ting Tsai, Wei-Hsiu Liu   +3 more
doaj   +1 more source