Results 31 to 40 of about 2,567 (167)
BMC Cell Biology, 2011 Background Purifying stem cells is an inevitable process for further investigation and cell-therapy. Sorting side population (SP) cells is generally regarded as an effective method to enrich for progenitor cells. This study was to explore whether sorting
Yu Tao +8 more
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Cellular and Molecular Gastroenterology and Hepatology, 2023 Background and aims: Active intestinal stem cells are prone to injury by ionizing radiation. We previously showed that upon radiation-induced injury, normally quiescent reserve intestinal stem cells (rISCs) (marked by BMI1) are activated by Musashi-1 ...
Emilia J. Orzechowska-Licari +2 more
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miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma
Tumor Biology, 2015 Increasing evidences have revealed that microRNAs regulate various biological processes. However, the roles of miR-761 have not been investigated in ovarian cancer. Here, we found that miR-761 expression was significantly lower in ovarian cancer tissues than in their paired noncancerous tissues.
Can, Shi, Zhenyu, Zhang
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Cellular & Molecular Biology Letters, 2018 Background Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer, with a poor prognosis. Deregulation of WNT and NOTCH signaling pathways is important in ESCC progression, which can be due to either ...
Mohammad Reza Abbaszadegan +3 more
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Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation
Neoplasia: An International Journal for Oncology Research, 2019 Glioblastoma multiforme (GBM) is a lethal brain tumor with a mean survival time of 1 year. One major reason for therapeutic failure is that GBM cells have an extraordinary capacity to invade normal brain tissue beyond the surgical margin, accounting for ...
Jang-Chun Lin +4 more
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The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins
Cell Reports, 2015 Members of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance.
Ning Li +23 more
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Cloning and expression analysis of DnMSI1 gene in orchid species Dendrobium nobile Lindl
Plant Signaling & Behavior, 2022 WD40 repeat proteins, the homologs of yeast MSI1, are conserved in plants, participating in protein complexes and playing fundamental functions in plant development.
Baolu Cui +4 more
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Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion [PDF]
Journal of Cell Communication and Signaling, 2015 Deregulation of developmental signaling pathways such as Wnt/b-catenin and NOTCH are commonly observed in different cancers. A normal wnt pathway is essential for development and tissue homeostasis to preserve a normal balance between the differentiation and proliferation.
Meysam, Moghbeli +5 more
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Nature Communications, 2022 MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound ...
Michelle M. Kameda-Smith +30 more
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MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. [PDF]
Proceedings of the National Academy of Sciences, 1989 We have previously demonstrated that the IRA1-encoded protein inhibits the function of the RAS protein in a fashion antagonistic to the function of the CDC25 protein in the RAS-cAMP pathway in Saccharomyces cerevisiae. In an attempt to identify genes involved in the regulation of this pathway, high-copy-number plasmid suppressors of the heat shock ...
R, Ruggieri +5 more
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