Results 41 to 50 of about 2,567 (167)
Cellular Physiology and Biochemistry, 2017 Background/Aims: Lung cancer is one of the leading causes for cancer mortality. The poor therapeutic outcome of non-small cell lung carcinoma (NSCLC) is mainly due to late diagnosis and chemoresistance. In this study, we investigated the role of Musashi1
Yaoguo Lang +8 more
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Molecular Oncology, 2015 Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. Additional MSI1 targets include the
Lan Lan +19 more
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Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
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Effects of Tumor Microenvironment on Lung Cancer Stem Cells: Bidirectional Regulatory Mechanisms
Cancer Medicine, Volume 15, Issue 4, April 2026.ABSTRACT Lung cancer, with a high mortality rate, poses challenges in treatment due to its invasiveness and heterogeneity. Lung cancer stem cells (LCSCs) are considered key contributors to recurrence and metastasis because of their self‐renewal, pluripotency, and drug resistance.
Hongyi Lai +6 more
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BMC Cancer, 2008 Background Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and ...
Shen Jiajie +4 more
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New Phytologist, Volume 249, Issue 5, Page 2241-2250, March 2026.Summary Subject to an ever‐changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and integrating these variations to facilitate adaptation.
Rory Osborne
wiley +1 more source
Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein
Scientific Reports, 2022 The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation and is involved in cell proliferation and tumorigenesis.
Nitchakan Darai +5 more
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Journal of Integrative Agriculture, 2021 The shortage of groundwater resources is a considerable challenge for winter wheat production on the North China Plain. Water-saving technologies and procedures are thus urgently required. To determine the water-saving potential of using micro-sprinkling
Li-chao ZHAI +6 more
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Plant Biotechnology Journal, Volume 24, Issue 2, Page 954-969, February 2026.ABSTRACT Cadmium (Cd) pollution is a growing global issue that poses significant threats to ecosystems and human health. N6‐methyladenosine (m6A) plays an essential role in regulating plant growth and stress responses, but the biological functions and regulatory mechanisms of m6A core enzymes under Cd stress remain largely unexplored. In this study, we
Mengzhuo Lin +9 more
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Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways
MedComm, Volume 7, Issue 1, January 2026.Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho +18 more
wiley +1 more source