Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival [PDF]
Molecular Cancer, 2010 Background Musashi1 (Msi1) is a conserved RNA-binding protein that regulates the Notch and Wnt pathways, and serves as a stem cell marker in the breast and other tissues.
Luiz O F Penalva +2 more
exaly +8 more sources
The oncogene Musashi1 encodes novel miRNAs in breast cancer [PDF]
Scientific Reports, 2023 RNA-binding protein Musashi1 (MSI1) shows an increased expression level in several cancers and has been introduced as a prognostic marker in some malignancies.
Liana Lachinani +7 more
doaj +4 more sources
Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae [PDF]
Frontiers in Cell and Developmental Biology, 2023 Acetylcholine, a vital neurotransmitter, plays a multifarious role in the brain and peripheral nervous system of various organisms. Previous research has demonstrated the proximity of cholinergic neurons to serotonergic neurons in the apical organ of sea
Junko Yaguchi +2 more
doaj +2 more sources
Dental pulp stem cells overexpressing hepatocyte growth factor facilitate the repair of DSS-induced ulcerative colitis [PDF]
Stem Cell Research & Therapy, 2021 Background Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study aimed to investigate the therapeutic
Ning Li +9 more
doaj +2 more sources
Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B [PDF]
Scientific ReportsThe Musashi family of sequence-specific RNA binding proteins (Musashi1 and Musashi2) serve a critical role in mediating both physiological and pathological stem cell function in many tissue types by repressing the translation of target mRNAs that encode ...
Katherine Bronson +7 more
doaj +2 more sources
The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma [PDF]
Cells, 2021 Medulloblastoma is the most common malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved survival in recent years, but patients are frequently left with devastating neurocognitive and other sequelae ...
Mirella Baroni +8 more
doaj +2 more sources
The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs [PDF]
Scientific ReportsThe pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses.
Jewel Banik +12 more
doaj +2 more sources
Upregulation of musashi1 increases malignancy of hepatocellular carcinoma via the Wnt/β-catenin signaling pathway and predicts a poor prognosis [PDF]
BMC Gastroenterology, 2019 Background Hepatocellular carcinoma (HCC) is a common human malignant cancer due to a high metastatic capacity and the recurrence rate is also high.
Qiuhua Liu, Cuijie Zhou, Bo Zhang
doaj +2 more sources
Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells [PDF]
BMC Cancer, 2008 Background Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and ...
Shen Jiajie +4 more
doaj +3 more sources
Identification of a novel intronic enhancer responsible for the transcriptional regulation of
Molecular Brain, 2011 Background The specific genetic regulation of neural primordial cell determination is of great interest in stem cell biology. The Musashi1 (Msi1) protein, which belongs to an evolutionarily conserved family of RNA-binding proteins, is a marker for neural
Kawase Satoshi +9 more
doaj +3 more sources