Results 31 to 40 of about 1,599 (196)

Optimization of RiPCA for the Live‐Cell Detection of Pre‐MicroRNA‐Protein Interactions

ChemBioChem, Volume 23, Issue 24, December 16, 2022., 2022
Interest in studying reported, but under‐characterized RNA‐protein interactions (RPI) warrants the development of tools to detect and validate these interactions. RiPCA is a cell‐based assay capable of detecting pre‐miRNA‐protein interactions in a sequence‐specific manner.
Sydney L. Rosenblum, Amanda L. Garner
wiley   +1 more source

Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor‐initiating cells

Brain Pathology, Volume 31, Issue 5, September 2021., 2021
We implicate fibrinogen in glioblastoma as a mediator of the invasive properties of brain tumour initiating cells, and as a target for therapy to reduce tumorigenecity Abstract Glioblastomas (GBMs) are highly aggressive, recurrent, and lethal brain tumors that are maintained via brain tumor‐initiating cells (BTICs).
Lauren Dzikowski, Reza Mirzaei, Susobhan Sarkar, Mehul Kumar, Pinaki Bose, Anita Bellail, Chunhai Hao, V. Wee Yong   +7 more
wiley   +1 more source

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

STEM CELLS Translational Medicine, Volume 10, Issue 7, Page 1081-1094, July 2021., 2021
Proposed model of glucosylsphingosine (GlcSph)‐mediated lysosomal dysfunction in neuronopathic Gaucher disease neurons. Mutant β‐glucocerebrosidase (GCase) causes the accumulation of glucosylceramide (GlcCer), which is converted to GlcSph by acid ceramidase in the lysosome.
Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman   +6 more
wiley   +1 more source

Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging

Aging Cell, Volume 20, Issue 6, June 2021., 2021
The current work reveals that amplifying intrinsic levels of the redox transcription factor, NRF2, before a certain critical period (CP) of aging (13–15 months), can rescue the age‐related decline in neural stem cell function in rats. This finding has fundamental implications for not only understanding neural stem cell biology, but also advantageously ...
Annadurai Anandhan, Konner R. Kirwan, Mandi J. Corenblum, Lalitha Madhavan   +3 more
wiley   +1 more source

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. [PDF]

, 2005
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-
Bajpai, Ruchi, Dougherty, Joseph D, Freije, William A, Geschwind, Daniel H, Groszer, Matthias, Imura, Tetsuya, Kelly, Theresa K, Kim, Kevin J, Kornblum, Harley I, Liu, Xin, Nakano, Ichiro, Nelson, Stanley F, Ou, Jing, Paucar, Andres A, Sofroniew, Michael V, Terskikh, Alexey V, Wu, Hong, Zewail, Amani   +17 more
core   +2 more sources

Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt β‐Catenin Signaling Pathway

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
Colorectal cancer (CRC) is the third most common cause of cancer‐related death worldwide in terms of both its rates of incidence and mortality. Due to serious side effects associated with conventional chemotherapeutic treatments, many natural products with fewer adverse side effects have been considered as potential treatment options.
Mehran Pashirzad, Thomas P. Johnston, Amirhossein Sahebkar, Ashok Pandurangan   +3 more
wiley   +1 more source

A Two‐Stage Process for Differentiation of Wharton’s Jelly‐Derived Mesenchymal Stem Cells into Neuronal‐like Cells

Stem Cells International, Volume 2021, Issue 1, 2021., 2021
With no permanent cure for neurodegenerative diseases, the symptoms reappear shortly after the withdrawal of medicines. A better treatment outcome can be expected if the damaged neurons are partly replaced by functional neurons and/or they are repaired using trophic factors.
Zaffar Equbal, Prakash N. Baligar, Madhulika Srivastava, Asok Mukhopadhyay, Francisco J. Rodr guez Lozano   +4 more
wiley   +1 more source

Characterization of the RNA-binding protein Musashi1 in zebrafish

Brain Research, 2012
Musashi (Msi) is an evolutionarily conserved gene family of RNA-binding proteins (RBPs) that is preferentially expressed in the nervous system. The first member of the Msi family was identified in Drosophila. Drosophila Msi plays an important role in regulating asymmetric cell division of the sensory organ precursor cells.
Shibata, Shinsuke, Umei, Masahiko, Kawahara, Hironori, Yano, Masato, Makino, Shinji, Okano, Hideyuki   +5 more
openaire   +2 more sources

Musashi mediates translational repression of the Drosophila hypoxia inducible factor. [PDF]

, 2016
Adaptation to hypoxia depends on a conserved α/β heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose α-subunit is regulated by oxygen through different concurrent mechanisms.
Acevedo, Julieta María, Bertolin, Agustina Paola, Blanco Obregón, Dalmiro Manuel, Gándara, Lautaro, Kanda, Hiroshi, Katz, Maximiliano Javier, Okano, Hideyuki, Pozzi, María Berta, Sorianello, Eleonora Mariana, Srebrow, Anabella, Wappner, Pablo, Yano, Masato   +11 more
core   +1 more source

MicroRNA-331 inhibits development of gastric cancer through targeting musashi1

World Journal of Gastrointestinal Oncology, 2019
The molecular mechanisms involved in microRNAs (miRNAs) have been extensively investigated in gastric cancer (GC). However, how miR-331 regulates GC pathogenesis remains unknown.To illuminate the effect of miR-331 on cell metastasis and tumor growth in GC.The qRT-PCR, CCK8, Transwell, cell adhesion, Western blot, luciferase reporter and xenograft tumor
Yang, Lei-Ying, Song, Guang-Le, Zhai, Xiao-Qian, Wang, Li, Liu, Qin-Lai, Zhou, Ming-Shun   +5 more
openaire   +2 more sources