Results 41 to 50 of about 1,599 (196)

Musashi1: A stem cell marker no longer in search of a function [PDF]

Cell Cycle, 2008
One of the earliest genes identified with stem and early progenitor cells is the RNA-binding protein, Musashi1 (Msi1). Through gene profiling of mammary epithelial cells transduced with Msi1, a unique autocrine signaling pathway was identified that activates both the Wnt and Notch pathways.
Robert I, Glazer, Xiao-Yang, Wang, Hongyan, Yuan, Yuzhi, Yin   +3 more
openaire   +2 more sources

Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa. [PDF]

PLoS ONE, 2013
OBJECTIVE: Upregulation of the RNA-binding protein Musashi-1 (Msi1) has been shown to occur in rat gastric corpus mucosa after ethanol-induced mucosal injury. However, there is no direct evidence linking Msi1 with gastric regeneration.
Tetsufumi Takahashi, Hidekazu Suzuki, Takao Imai, Shinsuke Shibata, Yoshiaki Tabuchi, Kanji Tsuchimoto, Hideyuki Okano, Toshifumi Hibi   +7 more
doaj   +1 more source

Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation

Neoplasia: An International Journal for Oncology Research, 2019
Glioblastoma multiforme (GBM) is a lethal brain tumor with a mean survival time of 1 year. One major reason for therapeutic failure is that GBM cells have an extraordinary capacity to invade normal brain tissue beyond the surgical margin, accounting for ...
Jang-Chun Lin, Jo-Ting Tsai, Tsu-Yi Chao, Hsin-I Ma, Wei-Hsiu Liu   +4 more
doaj   +1 more source

The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer- Related Genes and Is an Indicator of Poor Prognosis [PDF]

, 2012
Musashi1 (Msi1) is a highly conserved RNA-binding protein that is required during the development of the nervous system. Msi1 has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation, and has also ...
Abreu, Raquel de Sousa, Anant, Shrikant, Burns, Suzanne C., Burton, Tarea L., Dubuc, Adrian M., Gelfond, Jonathan A., Janga, Sarath Chandra, Korshunov, Andrey, Northcott, Paul A., Penalva, Luiz O. F., Pfister, Stefan M., Qiao, Mei, Remke, Marc, Smith, Andrew D., Subramaniam, Dharmalingam, Suresh, Uthra, Taylor, Michael D., Uren, Philip J., Vo, Dat T., Vogel, Christine   +19 more
core   +1 more source

Musashi1 RNA‐binding protein regulates oligodendrocyte lineage cell differentiation and survival

Glia, 2007
AbstractExpression of Musashi1 (Msi1), an evolutionarily conserved RNA‐binding protein, in neural stem cells of the subventricular zone in the postnatal and adult CNS indicates a potential role in the generation of oligodendrocytes. We now show Msi1 expression in a subset of oligodendrocyte progenitor (OP) cells in white matter areas temporally and ...
Dobson, Nicole R., Zhou, Yong‐Xing, Flint, Nicole C., Armstrong, Regina C.   +3 more
openaire   +3 more sources

Musashi1, a potential prognostic marker in esophageal squamous cell carcinoma

Oncology Reports, 2017
Esophageal cancer ranks as the sixth leading cause of cancer-related deaths worldwide. Cancer stemness is mainly considered to be the key factor for cancer recurrence particularly in esophageal cancer. It is important to identify cancer stem cell markers as targets in future therapies.
Qin, Guohui, Lian, Jingyao, Yue, Dongli, Chen, Xinfeng, Nan, Shufeng, Qi, Yu, Li, Bing, Cui, Guanghui, Li, Xiangnan, Zhao, Song, Zhang, Yi   +10 more
openaire   +3 more sources

Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA

Molecules, 2017
Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation.
Ryo Iwaoka, Takashi Nagata, Kengo Tsuda, Takao Imai, Hideyuki Okano, Naohiro Kobayashi, Masato Katahira   +6 more
doaj   +1 more source

Identification and characterization of a novel multipotent sub-population of Sca-1⁺ cardiac progenitor cells for myocardial regeneration. [PDF]

PLoS ONE, 2011
The cardiac stem/progenitor cells from adult mice were seeded at low density in serum-free medium. The colonies thus obtained were expanded separately and assessed for expression of stem cell antigen-1 (Sca-1). Two colonies each with high Sca-1 (CSH1; 95.
Michitaka Takamiya, Khawaja H Haider, Muhammad Ashraf   +2 more
doaj   +1 more source

Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro

Pediatric Research, 2019
Glioblastoma (GBM) is the most aggressive form of glioma in adults and children and is associated with very poor prognosis. Pediatric tumors are biologically distinct from adult GBM and differ in response to current GBM treatment protocols. Regarding pediatric GBM, new drug combinations and the molecular background of chemotherapy effects need to be ...
Pötschke, Rebecca, Gielen, Gerrit, Pietsch, Torsten, Kramm, Christof, Klusmann, Jan-Henning, Hüttelmaier, Stefan, Kühnöl, Caspar D.   +6 more
openaire   +3 more sources

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state [PDF]

, 2014
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation.
Beard, Ber, Busch, Cancer Genome Atlas Network, Chakrabarti, Chigurupati, Colitti, Das, Dickson, dos Santos, Feng, Foubert, Han, Hirata, Imai, Ingolia, Jangi, Katz, Kawahara, Kayahara, Kharas, Kim, Knight, Lambert, Lee, Leong, Lobry, MacNicol, Mani, Mortazavi, Muto, Nakamura, Okabe, Okano, Okano, Park, Parker, Polyak, Ray, Reinke, Sakakibara, Sethi, Shapiro, Takahashi, Timmerman, Venables, Verhaak, Wang, Wang, Warzecha, Yamamoto, Yu, Zavadil   +52 more
core   +3 more sources