Results 21 to 30 of about 1,599 (196)

Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation [PDF]

Molecular Reproduction and Development, 2012
AbstractThe mRNA translational control protein, Musashi, plays a critical role in cell fate determination through sequence‐specific interactions with select target mRNAs. In proliferating stem cells, Musashi exerts repression of target mRNAs to promote cell cycle progression.
Karthik, Arumugam, Melanie C, Macnicol, Angus M, Macnicol   +2 more
openaire   +2 more sources

Musashi1 expression is negatively correlated with numb expression in brain metastases. [PDF]

Medicine (Baltimore), 2020
Abstract The expression of tumor stem cell markers musashi1 (msi1) and numb in brain metastases were detected to explore their roles in the development of brain metastases. A total of 51 cases of brain metastasis, 29 cases of primary tumor and 15 cases of normal brain tissue were selected.
Dong Y, Li J, Liu R, Zhao Z, Wang S, Cui K.   +5 more
europepmc   +3 more sources

Increased expression of MUSASHI1 in epithelial breast cancer cells is due to down regulation of miR-125b

BMC Molecular and Cell Biology, 2021
Background Musashi1 (MSI1) is an oncogenic protein with a crucial role in the proliferation and characteristics of the epithelial cells in breast cancer. The change in expression of MSI1 has a role in solid tumor progression.
Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi   +4 more
doaj   +1 more source

NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms. [PDF]

Reprod Med Biol
Abstract Background NR5A1 plays essential roles in the development of various tissues, including the ventromedial hypothalamus, pituitary gonadotrope, adrenal cortex, spleen, testis, and ovary. Additionally, NR5A1‐positive cells in these tissues exhibit developmental and functional heterogeneity.
Inoue M, Miyabayashi K, Shima Y.
europepmc   +2 more sources

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Cell Reports, 2023
Summary: The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic development remains poorly understood.
Youwei Chen, Ying Chen, Qianyan Li, Huahua Liu, Jiazhen Han, Hailin Zhang, Liming Cheng, Gufa Lin   +7 more
doaj   +1 more source

FRI291 Musashi1 And Musashi2 Mark Distinct Pituitary Stem Cell Populations [PDF]

J Endocr Soc, 2023
Abstract Disclosure: Y. Rahmatallah: None. J. Banik: None. K. Bronson: None. M.C. MacNicol: None. The cell plastic state of the pituitary is required to meet the changing demands upon pituitary function and may also result in these cells being more vulnerable to malignant transformation.
Rahmatallah, Yasir, Banik, Jewel, Bronson, Katherine, MacNicol, Melanie C   +3 more
europepmc   +2 more sources

Novel strategies to reverse chemoresistance in colorectal cancer

Cancer Medicine, Volume 12, Issue 10, Page 11073-11096, May 2023., 2023
Chemoresistance is the major cause of treatment failure and disease relapse in colorectal cancer (CRC). In addition to some common reversal measures, some novel strategies have sprouted in recent years, including drug repurposing, gene therapy, protein inhibitor, natural herbal compounds, new drug delivery system, and combination therapy, which promise
Shu‐Chang Ma, Jia‐Qi Zhang, Tian‐Hua Yan, Ming‐Xing Miao, Ye‐Min Cao, Yong‐Bing Cao, Li‐Chao Zhang, Ling Li   +7 more
wiley   +1 more source

Methods to study adult hippocampal neurogenesis in humans and across the phylogeny

Hippocampus, Volume 33, Issue 4, Page 271-306, April 2023., 2023
Abstract The hippocampus hosts the continuous addition of new neurons throughout life—a phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the occurrence of AHN in more than 110 mammalian species, including humans, and discuss the further validation of these data by single‐cell RNAseq and other alternative techniques. In this regard,
Julia Terreros‐Roncal, Miguel Flor‐García, Elena P. Moreno‐Jiménez, Carla B. Rodríguez‐Moreno, Berenice Márquez‐Valadez, Marta Gallardo‐Caballero, Alberto Rábano, María Llorens‐Martín   +7 more
wiley   +1 more source

The Functions and Mechanisms of Tendon Stem/Progenitor Cells in Tendon Healing

Stem Cells International, Volume 2023, Issue 1, 2023., 2023
Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics and is characterized by pain and limitation of joint function. Due to the difficulty of spontaneous tendon healing, and the scar tissue and low mechanical properties that usually develops after healing. Therefore, the healing of tendon injury remains a clinical
Jingwei Lu, Hui Chen, Kexin Lyu, Li Jiang, Yixuan Chen, Longhai Long, Xiaoqiang Wang, Houyin Shi, Sen Li, Gerald A. Colvin   +9 more
wiley   +1 more source

Molecular Mechanisms and Clinical Applications of Neural Regeneration Through Dental Pulp Stem Cells. [PDF]

Stem Cells Int
Neural injuries affecting both the central nervous system (CNS) and peripheral nervous system (PNS) pose a great clinical challenge due to the neural tissue’s limited self‐regenerative capacity. Human dental pulp stem cells (hDPSCs), derived from the neural crest and easily obtained from extracted teeth, exhibit considerable potential for neural ...
Wang X, Yi B.
europepmc   +2 more sources