Neural stem and progenitor cell fate transition requires regulation of Musashi1 function [PDF]
BMC Developmental Biology, 2015 There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintained by the mRNA-binding protein, Musashi1 through repression of translation of key mRNAs encoding cell cycle inhibitory proteins. The mechanism by
MacNicol, Angus M +3 more
openaire +2 more sources
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs [PDF]
, 2014 Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss ...
Al-Shahrour, Fatima +11 more
core +1 more source
Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome. [PDF]
PLoS ONE, 2013 Glioblastoma multiforme (GBM) is the most common primary malignant adult brain tumor and is associated with poor survival. Recently, stem-like cell populations have been identified in numerous malignancies including GBM.
Zev A Binder +15 more
doaj +1 more source
Pluripotent human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy [PDF]
, 2016 The incidence of neurological complications and fatalities associated with Hand, Foot & Mouth disease has increased over recent years, due to emergence of newly-evolved strains of Enterovirus 71 (EV71).
Heng, Alexis Boon Chin * +9 more
core +1 more source
STEM CELLS Translational Medicine, Volume 9, Issue 3, Page 328-341, March 2020., 2020 Abstract Neural crest (NC) cells are a multipotent stem cell population that give rise to a diverse array of cell types in the body, including peripheral neurons, Schwann cells (SC), craniofacial cartilage and bone, smooth muscle cells, and melanocytes.
Pihu Mehrotra +3 more
wiley +1 more source
Human Keratinocytes Adopt Neuronal Fates After Transplantation in the Developing Rat Brain
Cell Transplantation, 2021 Human skin contains keratinocytes in the epidermis. Such cells share their ectodermal origin with the central nervous system (CNS). Recent studies have demonstrated that terminally differentiated somatic cells can adopt a pluripotent state, or can ...
Andrea Tenorio-Mina +12 more
doaj +1 more source
Zebrafish Stem/Progenitor Factor msi2b Exhibits Two Phases of Activity Mediated by Different Splice Variants [PDF]
, 2014 The Musashi (Msi) family of RNA-binding proteins is important in stem and differentiating cells in many species. Here, we present a zebrafish gene/protein trap line gt(msi2b-citrine)(ct) (57) (a) that expresses a Citrine fusion protein with endogenous ...
Bronner, Marianne E. +3 more
core +1 more source
Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1
Nature Communications, 2023 Human RNA binding protein Musashi-1 binds various host transcripts as well as Zika virus RNA in neural progenitor cells. Here, Chen et al. characterise the interactions between Musashi-1 and its binding site using a combination of molecular and ...
Xiang Chen +11 more
doaj +1 more source
Establishment and Characterization of Immortalized Minipig Neural Stem Cell Line
Cell Transplantation, 2017 Despite the increasing importance of minipigs in biomedical research, there has been relatively little research concerning minipig-derived adult stem cells as a promising research tool that could be used to develop stem cell-based therapies.
Sung S. Choi +8 more
doaj +1 more source
MicroRNAs in neural stem cells and neurogenesis
Frontiers in Neuroscience, 2012 MicroRNA (miRNA) is a type of short-length (~22 nt) non-coding RNA. Most miRNAs are transcribed by RNA polymerase II and processed by Drosha-DGCR8 and Dicer complexes in the cropping and dicing steps, respectively.
Hironori eKawahara +3 more
doaj +1 more source