Results 71 to 80 of about 1,599 (196)

Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia [PDF]

Journal of Neuroscience Research, 2002
AbstractBoth nestin and the neural RNA‐binding protein Musashi1 (Msi1) are expressed in neural stem cells in the subventricular zone. Neurogenesis in the hippocampus has received much attention, so we evaluated the expression of Msi1 and nestin in the adult rat hippocampus after transient forebrain ischemia.
Yoshiki, Yagita, Kazuo, Kitagawa, Tsutomu, Sasaki, Takaki, Miyata, Hideyuki, Okano, Masatsugu, Hori, Masayasu, Matsumoto   +6 more
openaire   +2 more sources

Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review). [PDF]

, 2014
Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the actualization and fine tuning of the genetic program of cells, both in development and in differentiated tissues.
DI LIEGRO, Carlo Maria, DI LIEGRO, Italia, SCHIERA, Gabriella   +2 more
core   +1 more source

Musashi1 Modulates Mammary Progenitor Cell Expansion through Proliferin-Mediated Activation of the Wnt and Notch Pathways [PDF]

Molecular and Cellular Biology, 2008
The RNA-binding protein Musashi1 (Msi1) is a positive regulator of Notch-mediated transcription in Drosophila melanogaster and neural progenitor cells and has been identified as a putative human breast stem cell marker. Here we describe a novel functional role for Msi1: its ability to drive progenitor cell expansion along the luminal and myoepithelial ...
Xiao-Yang, Wang, Yuzhi, Yin, Hongyan, Yuan, Toshiyuki, Sakamaki, Hideyuki, Okano, Robert I, Glazer   +5 more
openaire   +2 more sources

Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1

, 2008
Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a ...
Armstrong, D.L., Boerkoel, C.F., Choi, K., Clewing, J.M., Deguchi, K., Elizondo, L.I., Fujita, Y., Hirano, R., Huang, C., Inoue, K., Kanemura, Y., Lou, S., Lucke, T., Marwedel, K.M., Northrop, J., Okano, H., Powell, R., SantaCruz, K., Sloan, E.A., van der Kooy, D., Willaime-Morawek, S.   +20 more
core   +1 more source

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity [PDF]

, 2015
The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and ...
Baekelandt, Veerle, Font-Nieves, Míriam, Pereira, Leticia, Planas, Anna M., Pozas, Esther, Van Den Haute, Chris   +5 more
core   +3 more sources

Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT

BioFactors, Volume 51, Issue 1, January/February 2025.
The lichen mycobiont Stereocaulon alpinum has secondary metabolites include lobaric acid (LA). In this study, we examined the inhibitory activity of LA against the stemness potential of CRC cells and investigated the possible underlying mechanisms.
Sultan Pulat, Jaycee Augusto Gumiran Paguiri, Chathurika D. B. Gamage, Mücahit Varlı, Rui Zhou, So‐Yeon Park, Jae‐Seoun Hur, Hangun Kim   +7 more
wiley   +1 more source

Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation

Stem Cell Research & Therapy, 2022
Background Endometrial carcinoma is the most common gynecological cancer in Europe. Musashi-1 is known to be a key regulator of endometrial cancer stem cells and a negative prognostic marker.
Isabel Falke, Fabian M. Troschel, Heike Palenta, Maria T. Löblein, Kathrin Brüggemann, Katrin Borrmann, Hans Theodor Eich, Martin Götte, Burkhard Greve   +8 more
doaj   +1 more source

Site identification in high-throughput RNA-protein interaction data [PDF]

, 2012
Motivation: Post-transcriptional and co-transcriptional regulation is a crucial link between genotype and phenotype. The central players are the RNA-binding proteins, and experimental technologies [such as cross-linking with immunoprecipitation-(CLIP ...
Anders, Andrew D. Smith, Benjamini, Cameron, Chi, Chénard, Cléry, Corcoran, Emad Bahrami-Samani, Emily Hodges, Fedor V. Karginov, Gabriel, Gregory J. Hannon, Hafner, Hilbe, Hilbe, Hirschfeld, Hofmann, Jeremy R. Sanford, Katz, Kedde, Khorshid, Kishore, Kloosterman, Konig, König, le Sage, Lebedeva, Leung, Licatalosi, Licatalosi, Lim, Luiz O. F. Penalva, Lukong, Lunde, Mei Qiao, Mukherjee, Philip J. Uren, Polymenidou, Rashid, Sharp, Siomi, Smith, Smith, Sumner, Suzanne C. Burns, Tenenbaum, Tollervey, Tsuda, Ule, Uren, Wang, Wang, Xue, Yang, Yeo, Zhang, Zhang   +57 more
core   +1 more source

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells [PDF]

, 2004
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue,
Boehm, Bernhard O., Brenner, Rolf, Fiedler, Jörg, Gastl, Regina, Hermann, Andreas, Lerche, Holger, Liebau, Stefan, Maisel, Martina, Popa, M. Oana, Schwarz, Johannes, Storch, Alexander   +10 more
core  

Circular RNAs in human diseases

MedComm, Volume 5, Issue 9, September 2024.
Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang, Jin Zhang, Yuchen Yang, Zhuofeng Liu, Sijia Sun, Rui Li, Hui Zhu, Tian Li, Jin Zheng, Jie Li, Litian Ma   +10 more
wiley   +1 more source