Results 81 to 90 of about 1,599 (196)

Characterization of neural progenitor/stem cells derived from human embryonic stem cells

, 2010
Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers.
Noisa, Parinya, Noisa, Parinya
core   +1 more source

Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Volume 38, Issue 7, Page 3417-3443, July 2024.
Luteolin, a flavonoid polyphenolic compound, has the ability to target multiple targets and pathways of the complex pathogenesis of related diseases, showing unique characteristics and benefits in the prevention or treatment of human diseases. Abstract Natural products are closely associated with human health.
Mingtao Zhu, Yanping Sun, Yang Su, Wei Guan, Yu Wang, Jianwei Han, Shuang Wang, Bingyou Yang, Qiuhong Wang, Haixue Kuang   +9 more
wiley   +1 more source

RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma [PDF]

Molecular and Cellular Biology, 2015
The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its mechanism of action has not yet been established comprehensively. To identify its target genes comprehensively and determine the main routes by which it influences glioblastoma phenotypes, we conducted ...
Philip J, Uren, Dat T, Vo, Patricia Rosa, de Araujo, Rebecca, Pötschke, Suzanne C, Burns, Emad, Bahrami-Samani, Mei, Qiao, Raquel, de Sousa Abreu, Helder I, Nakaya, Bruna R, Correa, Caspar, Kühnöl, Jernej, Ule, Jennifer L, Martindale, Kotb, Abdelmohsen, Myriam, Gorospe, Andrew D, Smith, Luiz O F, Penalva   +16 more
openaire   +2 more sources

RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. [PDF]

PLoS ONE, 2012
Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the progression of glioma.
Jun Muto, Takao Imai, Daisuke Ogawa, Yoshinori Nishimoto, Yohei Okada, Yo Mabuchi, Takeshi Kawase, Akio Iwanami, Paul S Mischel, Hideyuki Saya, Kazunari Yoshida, Yumi Matsuzaki, Hideyuki Okano   +12 more
doaj   +1 more source

Mutational landscape of RNA-binding proteins in human cancers [PDF]

, 2017
RNA Binding Proteins (RBPs) are a class of post-transcriptional regulatory molecules which are increasingly documented to be dysfunctional in cancer genomes. However, our current understanding of these alterations is limited.
Bhat-Nakshatri, Poornima, Gonzalez-Perez, Abel, Janga, Sarath Chandra, Nakshatri, Harikrishna, Neelamraju, Yaseswini   +4 more
core   +2 more sources

Mechanism of Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair

MedComm, Volume 5, Issue 5, May 2024.
Scientific hypothesis: After radiation exposure, lung cancer cells undergo DNA damage, triggering RBM17 to sense signals. MSI2, assisted by RBM17, translocates into the nucleus, where it interacts with ATR and CHK1, activating downstream pathways. This activation enhances the DNA damage repair. Upon repair completion, MSI2 and RBM17 dissociate from ATR
Hongjin Qu, Xiong Shi, Ying Xu, Hongran Qin, Junshi Li, Shanlin Cai, Jianpeng Zhao, Bingbing Wan, Yanyong Yang, Bailong Li   +9 more
wiley   +1 more source

Targeting mTOR as a Therapeutic Approach in Medulloblastoma [PDF]

, 2018
Mechanistic target of rapamycin (mTOR) is a master signaling pathway that regulates organismal growth and homeostasis, because of its implication in protein and lipid synthesis, and in the control of the cell cycle and the cellular metabolism.
Aldareguía Fernández, Juncal, García Camino, Idoia, Matheu Fernández, Ander, Odriozola, Ainitze   +3 more
core   +3 more sources

Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration – A review

Clinical &Experimental Ophthalmology, Volume 52, Issue 2, Page 148-166, March 2024.
Abstract Adult stem cells, present in various parts of the human body, are undifferentiated cells that can proliferate and differentiate to replace dying cells within tissues. Stem cells have specifically been identified in the cornea, trabecular meshwork, crystalline lens, iris, ciliary body, retina, choroid, sclera, conjunctiva, eyelid, lacrimal ...
Yuting Xiao, Charles N. J. McGhee, Jie Zhang   +2 more
wiley   +1 more source

Tissue-specific control of brain-enriched miR-7 biogenesis [PDF]

, 2013
MicroRNA (miRNA) biogenesis is a highly regulated process in eukaryotic cells. Several mature miRNAs exhibit a tissue-specific pattern of expression without an apparent tissue-specific pattern for their corresponding primary transcripts. This discrepancy
Choudhury, Nila Roy, Cáceres, Javier F, de Andrés-Aguayo, Luisa, de Lima Alves, Flavia, Graf, Thomas, Michlewski, Gracjan, Rappsilber, Juri   +6 more
core   +1 more source

Modulating Lineage Specification in Stem Cell Differentiation via Bioelectrical Stimulation Intensity Matching

Advanced Materials Interfaces, Volume 11, Issue 5, February 13, 2024.
Matching the bioelectrical stimulation intensity with the endogenous membrane potentials of cells derived from different tissues (osteogenic: −55.05 ± 4.22 mV, neurogenic: −84.8 ± 7.48 mV) can modulate osteogenic or neurogenic lineage commitment of stem cells by regulating protein adsorption and the activation of Wnt or Erk signaling.
Fengyi Zhang, Xiangyu Yan, Muyao Wu, Yumin Chen, Han Zhao, Chenguang Zhang, Pengrui Dang, Ling Wei, Fangyu Zhu, Ying Chen, Jinlin Song, Zhihong Li, Xuliang Deng, Wenwen Liu   +13 more
wiley   +1 more source